NS 398

Name: NS 398
Brand: Tocris Bioscience
SKU: 0942

Tocris Bioscience, part of Bio-Techne | Catalog # 0942

Citations (47)

COA / SDS

Cyclooxygenase-2 (COX-2) inhibitor

Key Product Details

Description:	Cyclooxygenase-2 (COX-2) inhibitor
Chemical Name:	N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	314.36

View Full Technical Details for NS 398

Technical Data
Citations

Biological Activity for NS 398

NS 398 is a selective cyclooxygenase-2 inhibitor (IC₅₀ values are 3.8 and > 100 μM for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro. Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo.

Compound Libraries for NS 398

NS 398 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for NS 398

M. Wt	314.36
Formula	C₁₃H₁₈N₂O₅S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	123653-11-2
PubChem ID	4553
InChi Key	KTDZCOWXCWUPEO-UHFFFAOYSA-N
Smiles	CS(=O)(=O)NC1=C(OC2CCCCC2)C=C(C=C1)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 398

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.44	100

Preparing Stock Solutions for NS 398

The following data is based on the product molecular weight 314.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.18 mL	15.91 mL	31.81 mL
5 mM	0.64 mL	3.18 mL	6.36 mL
10 mM	0.32 mL	1.59 mL	3.18 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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References for NS 398

References are publications that support the biological activity of the product.

Futaki NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen.Pharmacol. 1993 PMID: 8482483
Futaki NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 1994 PMID: 8140262
Elder The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. Int.J.Cancer 2002 PMID: 11992399