Cyclooxygenase-2 (COX-2) inhibitor
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Key Product Details
Description: | Cyclooxygenase-2 (COX-2) inhibitor |
Chemical Name: | N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 314.36 |
Citations for NS 398 (15)
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Citations are publications that use Bio-Techne products. Selected citations for NS 398 include:
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Messerschmidt et al.
(2019)
Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation.
Mol Vis.
25:329
PMID: 31341381 -
Bonfill-Teixidor et al.
(2017)
Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide.
J Neuroinflammation.
14:3
PMID: 28086956 -
Tunaru et al.
(2016)
Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor
PLoS One.
12:e0163633
PMID: 27662627 -
Tunaru et al.
(2016)
Arachidonic acid metabolite 19(S)-HETE induces vasorelaxation and platelet inhibition by activating prostacyclin(IP) receptor.
PLoS One.
11:e0163633
PMID: 27662627 -
Ho et al.
(2015)
Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus.
J Virol.
22:46
PMID: 26100815 -
Wei et al.
(2015)
Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat.
Hypertension.
65:1126
PMID: 25776070 -
Liu et al.
(2014)
Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress.
Antioxid Redox Signal.
21:1571
PMID: 24328731 -
Sugiyama et al.
(2013)
The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice.
Osteoporos Int.
24:383
PMID: 22349912 -
Buenestado et al.
(2012)
Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide.
Br J Pharmacol.
165:1877
PMID: 21913898 -
Font-Nieves et al.
(2012)
Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes.
J Biol Chem.
287:6454
PMID: 22219191 -
Chia et al.
(2011)
Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.
BMC Pharmacol.
11:10
PMID: 21955547 -
Bourquin et al.
(2011)
Systemic cancer therapy with a small molecule agonist of toll-like receptor 7 can be improved by circumventing TLR tolerance.
Cancer Res.
71:5123
PMID: 21697281 -
Sunters et al.
(2010)
Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i
J Biol Chem.
285:8743
PMID: 20042609 -
Wong et al.
(2009)
Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging.
Circ Res.
104:228
PMID: 19096033 -
Ray et al.
(2004)
Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus.
PLoS One.
78:12964
PMID: 15542648
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