NS 398

Name: NS 398
Brand: Tocris Bioscience
SKU: 0942

Catalog # 0942 | Tocris Bioscience a Bio-Techne Brand

Citations (14)

COA / SDS

Cyclooxygenase-2 (COX-2) inhibitor

Key Product Details

Description:	Cyclooxygenase-2 (COX-2) inhibitor
Chemical Name:	N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	314.36

View Full Technical Details for NS 398

Technical Data
Citations (14) / Reviews

Biological Activity for NS 398

NS 398 is a selective cyclooxygenase-2 inhibitor (IC₅₀ values are 3.8 and > 100 μM for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro. Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo.

Compound Libraries for NS 398

NS 398 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for NS 398

M. Wt	314.36
Formula	C₁₃H₁₈N₂O₅S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	123653-11-2
PubChem ID	4553
InChi Key	KTDZCOWXCWUPEO-UHFFFAOYSA-N
Smiles	CS(=O)(=O)NC1=C(OC2CCCCC2)C=C(C=C1)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 398

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.44	100

Preparing Stock Solutions for NS 398

The following data is based on the product molecular weight 314.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.18 mL	15.91 mL	31.81 mL
5 mM	0.64 mL	3.18 mL	6.36 mL
10 mM	0.32 mL	1.59 mL	3.18 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for NS 398

References are publications that support the biological activity of the product.

Elder The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. Int.J.Cancer 2002 PMID: 11992399
Futaki NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 1994 PMID: 8140262
Futaki NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen.Pharmacol. 1993 PMID: 8482483

Citations for NS 398 (15)

Showing 1 - 10 of 15 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for NS 398 include:

Messerschmidt et al. (2019) Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis. 25:329
PMID: 31341381
Bonfill-Teixidor et al. (2017) Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide. J Neuroinflammation. 14:3
PMID: 28086956
Tunaru et al. (2016) Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor PLoS One. 12:e0163633
PMID: 27662627
Tunaru et al. (2016) Arachidonic acid metabolite 19(S)-HETE induces vasorelaxation and platelet inhibition by activating prostacyclin(IP) receptor. PLoS One. 11:e0163633
PMID: 27662627
Ho et al. (2015) Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. J Virol. 22:46
PMID: 26100815
Wei et al. (2015) Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat. Hypertension. 65:1126
PMID: 25776070
Liu et al. (2014) Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress. Antioxid Redox Signal. 21:1571
PMID: 24328731
Sugiyama et al. (2013) The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice. Osteoporos Int. 24:383
PMID: 22349912
Buenestado et al. (2012) Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide. Br J Pharmacol. 165:1877
PMID: 21913898
Font-Nieves et al. (2012) Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes. J Biol Chem. 287:6454
PMID: 22219191
Chia et al. (2011) Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol. 11:10
PMID: 21955547
Bourquin et al. (2011) Systemic cancer therapy with a small molecule agonist of toll-like receptor 7 can be improved by circumventing TLR tolerance. Cancer Res. 71:5123
PMID: 21697281
Sunters et al. (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i J Biol Chem. 285:8743
PMID: 20042609
Wong et al. (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res. 104:228
PMID: 19096033
Ray et al. (2004) Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus. PLoS One. 78:12964
PMID: 15542648

There are no citations that match your criteria.