SC 560

Name: SC 560
Brand: tocris
SKU: 1550
Rating: 5 (1 reviews)

Catalog # 1550

Citations (1)

(1)

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$35 to United States

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Key Product Details

Description:	Cyclooxygenase-1 (COX-1) inhibitor
Chemical Name:	5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Purity:	≥98% (HPLC)
Molecular Weight:	352.74

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Biological Activity

SC 560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC₅₀ values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B₂, gastric PGE₂ and dermal PDE₂ production. Significantly reduces ovarian surface epithelial tumor growth in vivo. Orally active.

Technical Data

M. Wt	352.74
Formula	C₁₇H₁₂ClF₃N₂O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	188817-13-2
PubChem ID	4306515
InChi Key	PQUGCKBLVKJMNT-UHFFFAOYSA-N
Smiles	COC1=CC=C(C=C1)N1N=C(C=C1C1=CC=C(Cl)C=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.27	100
	ethanol	8.82	25

Preparing Stock Solutions

The following data is based on the product molecular weight 352.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.17 mL	28.35 mL
5 mM	0.57 mL	2.83 mL	5.67 mL
10 mM	0.28 mL	1.42 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References

References are publications that support the biological activity of the product.

Daikoku Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res. 2005 PMID: 15867369
Takeuchi COX inhibition and NSAID-induced gastric damage - roles in various pathogenic events. Curr.Top.Med.Chem. 2005 PMID: 15974942
Smith Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A 1998 PMID: 9789085

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for SC 560 include:

Fritz et al. (2016) Prostaglandin-dependent modulation of DArgic neurotransmission elicits inflammation-induced aversion in mice. J Clin Invest. 126:695
PMID: 26690700

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a COX-1 inhibitor

Name: Anonymous

Species: Rat

Assay Type: Ex Vivo

It is a higly lipophilic COX-1 inhibitor. It decreased tACPD-induced prostaglandin E2 in rat brain slice.

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Product Documents

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SC 560

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References

Citations (1)

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a COX-1 inhibitor

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