SC 236
Tocris Bioscience, part of Bio-Techne | Catalog # 3919
Selective cyclooxygenase-2 (COX-2) inhibitor
Key Product Details
Description
Selective cyclooxygenase-2 (COX-2) inhibitor
Alternative Names
SC 58236
Product Description
SC 236 is a selective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
401.79
Formula
C16H11ClF3N3O2S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide
CAS Number
170569-86-5
PubChem ID
9865808
InChI Key
NSQNZEUFHPTJME-UHFFFAOYSA-N
SMILES
ClC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(N)=O)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.18 | 100 | |
| Ethanol | 40.18 | 100 |
Preparing Stock Solutions
for SC 236
The following data is based on the product molecular weight 401.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.49 mL | 12.44 mL | 24.89 mL |
| 5 mM | 0.50 mL | 2.49 mL | 4.98 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.49 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Roche-Nagle Antimetastatic activity of a cyclooxygenase-2 inhibitor. Br.J.Cancer 2004 PMID: 15213717
- Penning Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib). J.Med.Chem. 1997 PMID: 9135032
- Gierse A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J.Biol.Chem. 1996 PMID: 8663121
Product Specific Notices for SC 236
For research use only
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