SC 236

Name: SC 236
Brand: Tocris Bioscience
SKU: 3919

Tocris Bioscience a Bio-Techne Brand

Catalog # 3919

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Key Product Details

Description:	Selective cyclooxygenase-2 (COX-2) inhibitor
Alternative Names:	SC 58236
Chemical Name:	4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide
Purity:	≥99% (HPLC)
Molecular Weight:	401.79

View Full Technical Details for SC 236

Biological Activity for SC 236

SC 236 is a selective COX-2 inhibitor (IC₅₀ values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for SC 236

SC 236 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SC 236

M. Wt	401.79
Formula	C₁₆H₁₁ClF₃N₃O₂S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	170569-86-5
PubChem ID	9865808
InChi Key	NSQNZEUFHPTJME-UHFFFAOYSA-N
Smiles	ClC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(N)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SC 236

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.18	100
	ethanol	40.18	100

Preparing Stock Solutions for SC 236

The following data is based on the product molecular weight 401.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.44 mL	24.89 mL
5 mM	0.50 mL	2.49 mL	4.98 mL
10 mM	0.25 mL	1.24 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Reconstitution Calculator

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References for SC 236

References are publications that support the biological activity of the product.

Roche-Nagle Antimetastatic activity of a cyclooxygenase-2 inhibitor. Br.J.Cancer 2004 PMID: 15213717
Penning Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib). J.Med.Chem. 1997 PMID: 9135032
Gierse A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J.Biol.Chem. 1996 PMID: 8663121

Citations for SC 236

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