4-1BB/TNFRSF9/CD137 Products
4-1BB, also known as CD137 and TNFRSF9, is a transmembrane TNF receptor superfamily member that is expressed as on various populations of activated T cell including CD4+, CD8+, memory CD8+, NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. 4-1BB binding by 4-1BB Ligand costimulates T cell proliferation, activation, and/or survival and can enhance the activation-induced cell death of repetitively stimulated T cells. 4-1BB can associate with OX40 on activated T cells, forming a complex that responds to either ligand and inhibits Treg and CD8+ T cell proliferation. Reverse signaling through 4-1BB Ligand inhibits the development of dendritic cells, B cells, and osteoclasts but supports mature dendritic cell survival and costimulates the proliferation and activation of mast cells.
55 results for "4-1BB/TNFRSF9/CD137" in Products
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4-1BB/TNFRSF9/CD137 Products
4-1BB, also known as CD137 and TNFRSF9, is a transmembrane TNF receptor superfamily member that is expressed as on various populations of activated T cell including CD4+, CD8+, memory CD8+, NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. 4-1BB binding by 4-1BB Ligand costimulates T cell proliferation, activation, and/or survival and can enhance the activation-induced cell death of repetitively stimulated T cells. 4-1BB can associate with OX40 on activated T cells, forming a complex that responds to either ligand and inhibits Treg and CD8+ T cell proliferation. Reverse signaling through 4-1BB Ligand inhibits the development of dendritic cells, B cells, and osteoclasts but supports mature dendritic cell survival and costimulates the proliferation and activation of mast cells.
55 results for "4-1BB/TNFRSF9/CD137" in Products
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #145501 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #158332 |
Applications : | Flow Cytometry |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | CyTOF-ready, ELISA Capture, Flow Cytometry, Functional Assay, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Simple Western, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | CyTOF-ready, Flow Cytometry, Functional Assay, Immunohistochemistry, Western Blot |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2356B |
Applications : | CyTOF-ready, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Simple Western, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | ELISA Detection, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Western Blot |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #158321 |
Applications : | Functional Assay |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #145501 |
Applications : | CyTOF-ready, Flow Cytometry, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | CyTOF-ready, Flow Cytometry, Immunocytochemistry/Immunofluorescence |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #158332 |
Applications : | CyTOF-ready, ELISA Capture, Flow Cytometry, Western Blot |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2356C |
Applications : | CyTOF-ready, Flow Cytometry, Functional Assay |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #158332 |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2356C |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #158306 |
Applications : | Block/Neutralize, Western Blot |
Clonality : | Polyclonal |
Host : | Goat IgG |
Applications : | ELISA Detection, Flow Cytometry, Western Blot |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #145501 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Mouse IgG2b Clone #145501 |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rat IgG2b Clone #158306R |
Applications : | Block/Neutralize |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #158332 |
Applications : | Flow Cytometry |
Clonality : | Monoclonal |
Host : | Rat IgG2a Clone #158332 |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2356C |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2356B |
Applications : | Flow Cytometry |
Recombinant Monoclonal Antibody.
Clonality : | Monoclonal |
Host : | Rabbit IgG Clone #2356B |
Applications : | Flow Cytometry |