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VE-Cadherin Products

VE-Cadherin, also known as Cadherin-5 and CD144, is a member of the atypical/type II subgroup of Cadherin homophilic adhesion proteins. A 90 kDa portion of the VE-Cadherin ECD can be shed in a metalloproteinase-dependent mechanism and may function as a VE-Cadherin antagonist. VE-Cadherin is expressed on the surface of vascular endothelial cells (EC) from early in embryogenesis through adulthood as well as in the placenta, on hematopoietic cell progenitors, and on a subpopulation of hematopoietic stem cells. It is a major protein component of adherens junctions between cells of the endothelium. VE-Cadherin supports the extension and stabilization of existing vascular sprouts. VE-Cadherin also regulates or is regulated by VEGF R2, type I and type II TGF-beta receptors, and other endothelial junction proteins such as JAM-C, Claudin-5, and N-Cadherin. Elevated levels of soluble VE-Cadherin are found in the serum of myocardial infarction, angina pectoris, rheumatoid arthritis, and colorectal cancer patients.

 

33 results for "VE-Cadherin" in Products

VE-Cadherin Products

VE-Cadherin, also known as Cadherin-5 and CD144, is a member of the atypical/type II subgroup of Cadherin homophilic adhesion proteins. A 90 kDa portion of the VE-Cadherin ECD can be shed in a metalloproteinase-dependent mechanism and may function as a VE-Cadherin antagonist. VE-Cadherin is expressed on the surface of vascular endothelial cells (EC) from early in embryogenesis through adulthood as well as in the placenta, on hematopoietic cell progenitors, and on a subpopulation of hematopoietic stem cells. It is a major protein component of adherens junctions between cells of the endothelium. VE-Cadherin supports the extension and stabilization of existing vascular sprouts. VE-Cadherin also regulates or is regulated by VEGF R2, type I and type II TGF-beta receptors, and other endothelial junction proteins such as JAM-C, Claudin-5, and N-Cadherin. Elevated levels of soluble VE-Cadherin are found in the serum of myocardial infarction, angina pectoris, rheumatoid arthritis, and colorectal cancer patients.

 

33 results for "VE-Cadherin" in Products

Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies

Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies

WB, Flow, CyTOF-ready, ICC
WB, Flow, CyTOF-ready, ICC
Catalog #: 1002-VC
BA
WB, Simple Western, IHC
WB
Catalog #: BAF1002
WB
Catalog #: FAB9381N
Flow
Catalog #: FAB9381G
Flow
Catalog #: FAB9381T
Flow
Catalog #: FAB9381S
Flow
Catalog #: FAB1002G
Flow
Catalog #: FAB1002N
Flow
Catalog #: BAM9381
WB, Flow
WB, Flow, CyTOF-ready
ELISA
Catalog #: FAB9381R
Flow
Catalog #: FAB1002T
Flow
BA
Catalog #: FAB1002V
Flow
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