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Tie-2 Products
Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3. Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.
52 results for "Tie-2" in Products
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Tie-2 Products
Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3. Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.
52 results for "Tie-2" in Products
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
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Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
Contains 4 membranes - each spotted in duplicate with 39 different RTK antibodies
Simple Plex Human Tie-2 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Clonality : | Polyclonal |
| Host : | Rabbit IgG |
| Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Western Blot |
| Source : | NS0 |
| Accession # : | Q02763 |
| Applications : | Bioactivity |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, Immunohistochemistry, Simple Western, Western Blot |
| Assay Range : | 156 - 10,000 pg/mL |
| Applications : | ELISA |
| Sensitivity : | 40.2 pg/mL |
| Assay Range : | 125 - 8,000 pg/mL (Cell Culture Supernates, Tissue Homogenates, Serum, EDTA Plasma, Heparin Plasma) |
| Applications : | ELISA |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #83711 |
| Applications : | Western Blot |
| Source : | HEK293 |
| Accession # : | AAA61139.1 |
| Applications : | Bioactivity |
| Clonality : | Polyclonal |
| Host : | Rabbit IgG |
| Applications : | Immunohistochemistry, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, Immunohistochemistry, Western Blot |
| Source : | NS0 |
| Accession # : | NP_001099207 |
| Applications : | Binding Activity |
Potent VEGFR inhibitor; also inhibits other RTKs
| Alternate Names : | Cabozantinib, BMS 907351 |
| Chemical Name : | N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide |
| Purity : | ≥98% (HPLC) |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #176222 |
| Applications : | Block/Neutralize, Western Blot |
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Western Blot |
| Source : | CHO |
| Accession # : | XP_020918337.1 |
| Applications : | Bioactivity |
