
Tie-2: Proteins and Enzymes
Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3. Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.
14 results for "Tie-2 Proteins and Enzymes" in Products
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Tie-2: Proteins and Enzymes
Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3. Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.
14 results for "Tie-2 Proteins and Enzymes" in Products
Source : | NS0 |
Accession # : | Q02763 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | NP_001099207 |
Applications : | Binding Activity |
Source : | CHO |
Accession # : | XP_020918337.1 |
Applications : | Bioactivity |
Source : | HEK293 |
Accession # : | AAA61139.1 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | O73791 |
Applications : | Binding Activity |
Source : | CHO |
Accession # : | XP_020918337.1 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | XP_005626754.1 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | XP_005626754.1 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | NP_001099207.1 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | CAA47857.1 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | AAA61139.1 |
Applications : | Bioactivity |
Source : | NS0 |
Accession # : | CAA47857 |
Applications : | Binding Activity |
Source : | HEK293 |
Accession # : | XP_005581645.1 |
Applications : | Bioactivity |
Source : | HEK293 |
Accession # : | XP_005581645.1 |
Applications : | Bioactivity |