Tie-2: Proteins and Enzymes
Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3.
Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for the embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.
Products:
15 results for "Tie-2 Proteins and Enzymes" in Products
15 results for "Tie-2 Proteins and Enzymes" in Products
Tie-2: Proteins and Enzymes
Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3.
Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for the embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.
Products:
| Source: | NS0 |
| Accession #: | Q02763 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | AAA61139.1 |
| Applications: | BA |
| Source: | HEK293 |
| Accession #: | AAA61139.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | CAA47857 |
| Applications: | Bind |
| Source: | CHO |
| Accession #: | XP_020918337.1 |
| Applications: | BA |
| Source: | CHO |
| Accession #: | XP_020918337.1 |
| Applications: | BA |
| Source: | HEK293 |
| Accession #: | XP_005581645.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | XP_005626754.1 |
| Applications: | BA |
| Source: | HEK293 |
| Accession #: | XP_005581645.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | NP_001099207 |
| Applications: | Bind |
| Source: | NS0 |
| Accession #: | CAA47857.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | XP_005626754.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | NP_001099207.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | O73791 |
| Applications: | Bind |
| Applications: | AC |