Sign In / Register
Tie-2: Proteins and Enzymes
Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3. Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.
14 results for "Tie-2 Proteins and Enzymes" in Products
Application
Conjugates
Low Endotoxin
Sample Size
Citations
Reviews
Tie-2: Proteins and Enzymes
Tie-2, also known as Tek, is a transmembrane receptor tyrosine kinase (RTK) that functions as a receptor for Angiopoietin family proteins. It is expressed by embryonic and adult endothelial cells, hematopoietic stem cells, and a circulating population of proangiogenic monocytes. Tie-2 signaling is activated by Angiopoietins-1 and -4, while it can be either activated or inhibited by Angiopoietins-2 and -3. Tie-2 plays an important role in maintaining vascular integrity by mediating endothelial cell-smooth muscle cell communication and inhibiting endothelial cell apoptosis. It is also required for embryonic development of the endocardium. In addition, Tie-2 signaling mediates the quiescence of bone marrow stem cells in response to osteoblast-produced Angiopoietin-1. This quiescence is critical for maintaining an ongoing hematopoietic capability in the bone marrow.
14 results for "Tie-2 Proteins and Enzymes" in Products
BA
| Source : | NS0 |
| Accession # : | Q02763 |
| Applications : | Bioactivity |
Catalog #:
3874-T2
Bind
| Source : | NS0 |
| Accession # : | NP_001099207 |
| Applications : | Binding Activity |
Catalog #:
10488-T2
BA
| Source : | CHO |
| Accession # : | XP_020918337.1 |
| Applications : | Bioactivity |
Catalog #:
AVI10727
BA
| Source : | HEK293 |
| Accession # : | AAA61139.1 |
| Applications : | Bioactivity |
Catalog #:
928-T2
Bind
| Source : | NS0 |
| Accession # : | O73791 |
| Applications : | Binding Activity |
Catalog #:
10492-T2
BA
| Source : | CHO |
| Accession # : | XP_020918337.1 |
| Applications : | Bioactivity |
Catalog #:
10781-T2
BA
| Source : | NS0 |
| Accession # : | XP_005626754.1 |
| Applications : | Bioactivity |
Catalog #:
10720-T2
BA
| Source : | NS0 |
| Accession # : | XP_005626754.1 |
| Applications : | Bioactivity |
Catalog #:
10458-T2
BA
| Source : | NS0 |
| Accession # : | NP_001099207.1 |
| Applications : | Bioactivity |
Catalog #:
10487-T2
BA
| Source : | NS0 |
| Accession # : | CAA47857.1 |
| Applications : | Bioactivity |
Catalog #:
10457-TI
BA
| Source : | NS0 |
| Accession # : | AAA61139.1 |
| Applications : | Bioactivity |
Catalog #:
762-T2
Bind
| Source : | NS0 |
| Accession # : | CAA47857 |
| Applications : | Binding Activity |
Catalog #:
10341-T2
BA
| Source : | HEK293 |
| Accession # : | XP_005581645.1 |
| Applications : | Bioactivity |
Catalog #:
10376-T2
BA
| Source : | HEK293 |
| Accession # : | XP_005581645.1 |
| Applications : | Bioactivity |
