9 results for "Inward Rectifier Potassium Channel Blockers Small Molecules and Peptides" in Products
Inward Rectifier Potassium Channel Blockers: Small Molecules and Peptides
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors (SUR).
Structurally, the pore-forming subunit of Kir channels is the α-subunit. It contains a single pore domain between two membrane spanning regions. Four α-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. Kir3.2 with Kir3.3.
Kir6 blocker; non-hydrolyzable AMP analog
| Chemical Name: | Adenosine-5'-[(β,γ)-imido]triphosphate tetralithium salt |
| Purity: | ≥90% (HPLC) |
Selective blocker of inward-rectifier K+ channels
| Purity: | ≥95% (HPLC) |
Kir2 channel blocker
| Chemical Name: | N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride |
| Purity: | ≥98% (HPLC) |
H1 antagonist. Also KV11.1 (hERG) and Kir6 (KATP) channel blocker
| Chemical Name: | α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol |
| Purity: | ≥98% (HPLC) |
Kir6 (KATP) channel blocker
| Alternate Names: | Glyburide |
| Chemical Name: | 5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide |
| Purity: | ≥98% (HPLC) |
Kir6 (KATP) channel blocker
| Alternate Names: | AG-EE 623ZW |
| Chemical Name: | 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid |
| Purity: | ≥98% (HPLC) |
Kir6 (KATP) blocker; displays high affinity for SUR1/Kir6.2 channels
| Alternate Names: | A-4166,Senaglinide |
| Chemical Name: | N-[[4-(1-Methylethyl)cyclohexyl]carbonyl]-D-phenylalanine |
Kir4.1 blocker
| Chemical Name: | 2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide |
| Purity: | ≥98% (HPLC) |
Kir 7.1 inhibitor; also inhibits Kir 6.2
| Chemical Name: | Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate |
| Purity: | ≥98% (HPLC) |
