ML 418

Tocris Bioscience, part of Bio-Techne | Catalog # 6889

Kir 7.1 inhibitor; also inhibits Kir 6.2
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Key Product Details

Description

Kir 7.1 inhibitor; also inhibits Kir 6.2

View all Inward Rectifier Potassium Channel Blockers »

Product Description

ML 418 is a Kir7.1 inhibitor (IC50 = 0.31 μM). Also inhibits Kir6.2 with similar potency. Displays >17-fold selectivity for Kir7.1 over Kir1.1, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 and Kir4.1. Active in vivo.

Product Specifications

Molecular Weight

377.87

Formula

C19H24CIN3O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

Isopropyl (1-((5-chloro-8-hydroxyquinolin-7-yl)methyl)piperidin-4-yl)carbamate

CAS Number

1928763-08-9

PubChem ID

91667465

InChI Key

CWIXCQOSULUGBT-UHFFFAOYSA-N

SMILES

CC(OC(NC1CCN(CC1)CC2=C(C3=C(C(Cl)=C2)C=CC=N3)O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.56 20

Preparing Stock Solutions for ML 418

The following data is based on the product molecular weight 377.87

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.23 mL 66.16 mL 132.32 mL
1 mM 2.65 mL 13.23 mL 26.46 mL
2 mM 1.32 mL 6.62 mL 13.23 mL
10 mM 0.26 mL 1.32 mL 2.65 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for ML 418

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ML 418

For research use only

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