AMP PNP

Name: AMP PNP
Brand: Tocris Bioscience
SKU: 6086
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6086

(1)

Citations (3)

COA / SDS

Kir6 blocker; non-hydrolyzable AMP analog

Key Product Details

Description:	K_ir6 blocker; non-hydrolyzable AMP analog
Chemical Name:	Adenosine-5'-[(β,γ)-imido]triphosphate tetralithium salt
Purity:	≥90% (HPLC)
Molecular Weight:	529.93

View Full Technical Details for AMP PNP

Technical Data
Citations / Reviews (1)

Biological Activity for AMP PNP

AMP PNP is a non-hydrolyzable AMP analog. K_ir6 (K_ATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules.

Technical Data for AMP PNP

M. Wt	529.93
Formula	C₁₀H₁₃Li₄N₆O₁₂P₃
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	72957-42-7
PubChem ID	44134521
InChi Key	FDBDJIGGLGUOPP-UHFFFAOYSA-J
Smiles	NC1=C2C(N([C@@H]3O[C@H](COP(OP(NP([O-])([O-])=O)([O-])=O)([O-])=O)[C@@H](O)[C@H]3O)C=N2)=NC=N1.[Li+].[Li+].[Li+].[Li+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMP PNP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	26.5	50

Preparing Stock Solutions for AMP PNP

The following data is based on the product molecular weight 529.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.77 mL	18.87 mL	37.74 mL
2.5 mM	0.75 mL	3.77 mL	7.55 mL
5 mM	0.38 mL	1.89 mL	3.77 mL
25 mM	0.08 mL	0.38 mL	0.75 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for AMP PNP

References are publications that support the biological activity of the product.

Yount Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage. Biochemistry 1971 PMID: 4326768
Hehl and Neumcke K_ATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur.Biophys.J. 1994 PMID: 7805625
Brady A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 1985 PMID: 2412134