Glibenclamide

Name: Glibenclamide
Brand: Tocris Bioscience
SKU: 0911
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0911

(2)

Citations (141)

COA / SDS

Kir6 (KATP) channel blocker

Key Product Details

Description:	K_ir6 (K_ATP) channel blocker
Alternative Names:	Glyburide
Chemical Name:	5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	494

View Full Technical Details for Glibenclamide

Technical Data
Citations / Reviews (2)

Biological Activity for Glibenclamide

Glibenclamide is an ATP-dependent K⁺ channel (K_ir6, K_ATP) and CFTR Cl^- channel blocker. Inhibits K_ir6 currents in the pancreas, by binding to the SUR1 regulatory subunit, causing an increase in intracellular Ca²⁺ and insulin secretion. Inhibits recombinant CFTR Cl^- channels with an IC₅₀ of 20 μM.

Compound Libraries for Glibenclamide

Glibenclamide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Glibenclamide

M. Wt	494
Formula	C₂₃H₂₈ClN₃O₅S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	10238-21-8
PubChem ID	3488
InChi Key	ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Smiles	COC1=C(C=C(Cl)C=C1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Glibenclamide

	Solvent	Max Conc. mM
Solubility
	DMSO	100
	ethanol	5

Preparing Stock Solutions for Glibenclamide

The following data is based on the product molecular weight 494.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.02 mL	10.12 mL	20.24 mL
5 mM	0.40 mL	2.02 mL	4.05 mL
10 mM	0.20 mL	1.01 mL	2.02 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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Reconstitution Calculator

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References for Glibenclamide

References are publications that support the biological activity of the product.

Robertson Potassium channel modulators: scientific applications and therapeutic promise. J.Med.Chem. 1990 PMID: 2187993
Sheppard and Welsh Effect of ATP-sensitive K⁺ channel regulators on cystic fibrosis transmembrane conductance regulator chloride channels. J.Gen.Physiol. 1992 PMID: 1281220
Brogden Glibenclamide: a review. Drugs 1979 PMID: 389600