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Glibenclamide

Inward Rectifier Potassium Channel Blockers Small Molecule
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0911/100

Key Product Details

Description: Kir6 (KATP) channel blocker
Alternative Names: Glyburide
Chemical Name: 5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sulphonyl]phenyl]ethyl]-2-methoxybenzamide
Purity: ≥99% (HPLC)
Molecular Weight: 494

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  • Glibenclamide prolongs action potential duration in LPS-treated cardiomyocytes
    Name: Anonymous
    Species: Other
    Assay Type: In Vitro
    Cell Line/Tissue: Ventricular cardiomyocytes
    Primary guinea pig ventricular cardiomyocytes were incubated with LPS for 6-10 h. Cells were patched and stimulated at a 1 Hz frequency. Action potentials were recorded before and after glibenclamide (5 microM) containing normal tyrode solution. Glibenclamide prolonged action potential duration in LPS-treated cardiomyocytes; indicating role of KATP channels.
    Glibenclamide Serum 0911
  • Glibenclamide was used to study combination drug effect with B blockers
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Glibenclamide was used in our lab to study combination drug effect. Beta blocker and glibenclamide was administered in combination and separately to study their pattern of action over blood glucose level.
    Glibenclamide Serum 0911

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