ML 133 hydrochloride

Name: ML 133 hydrochloride
Brand: Tocris Bioscience
SKU: 4549
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4549

(1)

Citations (8)

COA / SDS

Kir2 channel blocker

Key Product Details

Description:	K_ir2 channel blocker
Chemical Name:	N-[(4-Methoxyphenyl)methyl]-1-naphthalenemethanamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	313.82

View Full Technical Details for ML 133 hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for ML 133 hydrochloride

ML 133 hydrochloride is a selective blocker of inwardly rectifying K_ir2 potassium channels (IC₅₀ values are 1.8, 2.8, 2.9 and 4.0 μM at pH 7.4 for mK_ir2.1, hK_ir2.6, hK_ir2.2 and hK_ir2.3 respectively). Exhibits no effect on rK_ir1.1 (IC₅₀ > 300 μM); displays weak activity at hK_ir7.1 and rK_ir4.1 (IC₅₀ values are 33 and 76 μM).

Technical Data for ML 133 hydrochloride

M. Wt	313.82
Formula	C₁₉H₁₉NO.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1222781-70-5
PubChem ID	44247466
InChi Key	NGQIBUUFXDPHKT-UHFFFAOYSA-N
Smiles	COC(C=C3)=CC=C3CNCC1=C(C=CC=C2)C2=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 133 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.38	100

Preparing Stock Solutions for ML 133 hydrochloride

The following data is based on the product molecular weight 313.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.19 mL	15.93 mL	31.87 mL
5 mM	0.64 mL	3.19 mL	6.37 mL
10 mM	0.32 mL	1.59 mL	3.19 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for ML 133 hydrochloride

References are publications that support the biological activity of the product.

Wu A potent and selective small molecule K_ir2.1 inhibitor. Probe Reports from the NIH Molecular Libraries Pro 2010 PMID: 21433384
Wang Selective inhibition of the K_ir2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem.Biol. 2011 PMID: 21615117