Skip to main content

IL-6R alpha: Antibodies

IL-6R alpha is a transmembrane subunit of the receptor for Interleukin-6. It associates with gp130 which is a shared component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6R alpha. IL-6 plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis.

44 results for "IL-6R alpha Primary Antibodies" in Products

IL-6R alpha: Antibodies

IL-6R alpha is a transmembrane subunit of the receptor for Interleukin-6. It associates with gp130 which is a shared component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6R alpha. IL-6 plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis.

44 results for "IL-6R alpha Primary Antibodies" in Products

WB, Flow, CyTOF-ready, Neut
Flow, CyTOF-ready, Neut

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB1830V
Flow
ICC

Recombinant Monoclonal Antibody.

Flow, CyTOF-ready, ICC
WB, Flow
WB, Flow, IHC, CyTOF-ready, Neut
Catalog #: FAB227R
Flow
Catalog #: FAB227G
Flow
WB, Flow, CyTOF-ready, Neut

Recombinant Monoclonal Antibody.

Catalog #: FAB10346S
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB10346U
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB227RS
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB1830N
Flow
Catalog #: FAB1830R
Flow
Catalog #: FAB1830T
Flow
Catalog #: BAM1830
Flow, ICC
Catalog #: FAB227T
Flow
/ 2
Results Per Page
5 10 25 50