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98 results for "GSK-3 alpha/beta" in Products

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GSK-3 alpha/beta Products

GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.

CHIR 99021
Catalog #: 4423
(19)
Citations (2255)
Product Documents
Images (2)

Highly selective GSK-3 inhibitor; acts as Wnt activator

GMP Version Available: TB4423-GMP
GMP
Alternate Names:
CHIR99021,CT99021
Chemical Name:
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Purity:
≥98%
Cardiomyocyte derived from human induced pluripotent stem cells (hiPSCs) using CHIR 99021.
(2)
Catalog #
Availability
Size / Price
Qty
4423/50
4423/10
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Proteome Profiler Human Phospho-Kinase Array KitBest Seller

Catalog #: ARY003C
(12)
Citations (944)
Product Documents
Images (4)

Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins

Reactivity:
Human
Detection of human protein kinase phosphorylation in A549 Cell Line.
(4)
Catalog #
Availability
Size / Price
Qty
ARY003C
Bulk Order

phospho-GSK-3 alpha/beta (S21/S9) Antibody
Catalog #: AF1590
(1)
Citations (17)
Product Documents
Images (8)
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
WB, ICC/IF
Detection of Human Phospho-GSK-3a (S21) and GSK-3 beta (S9) antibody by Western Blot.
(8)
Catalog #
Availability
Size / Price
Qty
AF1590
AF1590-SP
Bulk Order

GSK-3 alpha/beta Antibody
Catalog #: AF2157
(4)
Citations (9)
Product Documents
Images (4)
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
WB, Flow, ICC/IF, CyTOF-ready
Detection of Human GSK-3a/ beta antibody by Western Blot.
(4)
Catalog #
Availability
Size / Price
Qty
AF2157
AF2157-SP
Bulk Order

GSK-3 alpha/beta [p Tyr216, p Tyr279] Antibody (SY26-05)
Catalog #: NBP2-67441
Citations (1)
Product Documents
Images (11)

Recombinant Monoclonal Antibody

Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Monoclonal Clone #SY26-05
Applications:
IHC, WB, ICC/IF, IP
(11)
Catalog #
Availability
Size / Price
Qty
NBP2-67441
Bulk Order

GSK-3 alpha/beta Antibody (1H8) - BSA Free
Catalog #: NB110-85523
Product Documents
Images (2)
Reactivity:
Human, Mouse, Rat, Porcine, Bovine, +5 More
Details:
Mouse IgG2B Monoclonal Clone #1H8
Applications:
IHC, WB, ICC/IF
Western Blot: GSK-3 alpha/beta Antibody (1H8) [NB110-85523]
(2)
Catalog #
Availability
Size / Price
Qty
NB110-85523
Bulk Order

SB 216763
Catalog #: 1616
Citations (251)
Product Documents
Images (1)

Potent, selective GSK-3 inhibitor

Chemical Name:
3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Purity:
≥98%
Potent, selective GSK-3 inhibitor
Catalog #
Availability
Size / Price
Qty
1616/1
1616/10
1616/50
Bulk Order

SB 415286
Catalog #: 1617
Citations (109)
Product Documents
Images (1)

Potent, selective GSK-3 inhibitor

Chemical Name:
3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
Purity:
≥98%
Potent, selective GSK-3 inhibitor
Catalog #
Availability
Size / Price
Qty
1617/50
1617/10
Bulk Order

GSK-3 alpha/beta Antibody (833916)
Catalog #: MAB25063
Citations (2)
Product Documents
Images (3)
Reactivity:
Human, Mouse
Details:
Mouse IgG2B Monoclonal Clone #833916
Applications:
WB, ICC/IF
Detection of Human GSK 3a and GSK-3 beta antibody by Western Blot.
(3)
Catalog #
Availability
Size / Price
Qty
MAB25063
MAB25063-SP
Bulk Order

BIO
Catalog #: 3194
Citations (85)
Product Documents
Images (1)

Potent GSK-3 inhibitor; also inhibits cdks

Alternate Names:
6BIO
Chemical Name:
(2'Z,3'E)-6-Bromoindirubin-3'-oxime
Purity:
≥98%
Potent GSK-3 inhibitor; also inhibits cdks
Catalog #
Availability
Size / Price
Qty
3194/50
3194/10
Bulk Order

Phospho-GSK-3 alpha/beta (S21/S9) DuoSet IC ELISA
Catalog #: DYC2630-2
Citations (3)
Product Documents
Images (1)
Reactivity:
Human, Mouse, Rat
Assay Range:
156-10000 pg/mL
Applications:
ELISA
Catalog #
Availability
Size / Price
Qty
DYC2630E
DYC2630-2
DYC2630-5
Bulk Order

GSK-3 alpha/beta [p Tyr279] Antibody (23GB4380)
Catalog #: NBP3-51276
Product Documents
Images (3)
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Monoclonal Clone #23GB4380
Applications:
WB, Flow, ICC/IF, Mycoplasma
GSK-3 alpha/beta [p Tyr279] Antibody (23GB4380)
(3)
Catalog #
Availability
Size / Price
Qty
NBP3-51276-100ul
NBP3-51276-20ul
Bulk Order

GSK-3 alpha/beta Antibody (23GB1100)
Catalog #: NBP3-51961
Images (2)
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Monoclonal Clone #23GB1100
Applications:
WB, Flow, ICC/IF, Mycoplasma
GSK-3 alpha/beta Antibody (23GB1100)
(2)
Catalog #
Availability
Size / Price
Qty
NBP3-51961-100ul
NBP3-51961-20ul
Bulk Order

phospho-GSK-3 alpha/beta (S21/S9) Antibody [Alexa Fluor™ Plus 405]
Catalog #: AF1590AFP405
Product Documents
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
WB, ICC/IF
Catalog #
Availability
Size / Price
Qty
AF1590AFP405-100UG
Bulk Order

GSK-3 alpha/beta [p Tyr216] Antibody (SR1908) - BSA Free
Catalog #: NBP3-21575
Product Documents
Images (1)

Recombinant Monoclonal Antibody

Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Monoclonal Clone #SR1908
Applications:
IHC, WB, ICC/IF, IP
Catalog #
Availability
Size / Price
Qty
NBP3-21575-100ul
NBP3-21575-50ul
Bulk Order

Kenpaullone
Catalog #: 1398
Citations (30)
Product Documents
Images (1)

GSK-3β inhibitor; also inhibits cdks

Chemical Name:
9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one
Purity:
≥98%
GSK-3β inhibitor; also inhibits cdks
Catalog #
Availability
Size / Price
Qty
1398/10
Bulk Order

TCS 2002
Catalog #: 3869
Citations (7)
Product Documents
Images (1)

Potent GSK-3β inhibitor

Chemical Name:
2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole
Purity:
≥98%
Potent GSK-3β inhibitor
Catalog #
Availability
Size / Price
Qty
3869/10
3869/50
Bulk Order

AR-A 014418
Catalog #: 3966
Citations (6)
Product Documents
Images (1)

Selective GSK-3 inhibitor

Chemical Name:
N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
Purity:
≥98%
Selective GSK-3 inhibitor
Catalog #
Availability
Size / Price
Qty
3966/10
3966/50
Bulk Order

A 1070722
Catalog #: 4431
Citations (5)
Product Documents
Images (1)

Highly potent, selective GSK-3 inhibitor

Chemical Name:
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
Purity:
≥98%
Highly potent, selective GSK-3 inhibitor
Catalog #
Availability
Size / Price
Qty
4431/50
4431/10
Bulk Order

TDZD 8
Catalog #: 6092
(1)
Citations (4)
Product Documents
Images (1)

Selective non-ATP competitive inhibitor of GSK 3β

Alternate Names:
NP 01139
Chemical Name:
2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
Purity:
≥98%
Selective non-ATP competitive inhibitor of GSK 3β
Catalog #
Availability
Size / Price
Qty
6092/10
6092/50
Bulk Order

PT-65
Catalog #: 7651
Citations (1)
Product Documents
Images (1)

Potent GSK3 Degrader (PROTAC®)

Chemical Name:
3-Amino-6-(4-((4-(4-(1-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)-1H-1,2,3-triazol-4-yl)butyl)piperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide
Purity:
≥98%
Potent GSK3 Degrader (PROTAC®)
Catalog #
Availability
Size / Price
Qty
7651/5
Bulk Order

TWS 119
Catalog #: 7405
Citations (11)
Product Documents
Images (1)

Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation

Chemical Name:
3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
Purity:
≥97%
Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation
Catalog #
Availability
Size / Price
Qty
7405/10
Bulk Order

GSK-3 alpha/beta [p Ser21] Antibody - BSA Free
Catalog #: NBP3-05443
Product Documents
Images (3)
Reactivity:
Human
Details:
Rabbit IgG Polyclonal
Applications:
WB, ELISA, IP
Western Blot: GSK-3 alpha/beta [p Ser21] AntibodyAzide and BSA Free [NBP3-05443]
(3)
Catalog #
Availability
Size / Price
Qty
NBP3-05443
Bulk Order

phospho-GSK-3 alpha/beta (S21/S9) Antibody [Alexa Fluor® 488]
Catalog #: AF1590G
Product Documents
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
WB, ICC/IF
Catalog #
Availability
Size / Price
Qty
AF1590G-100UG
Bulk Order

phospho-GSK-3 alpha/beta (S21/S9) Antibody [Alexa Fluor® 488]
Catalog #: AF1590G
Product Documents
Reactivity:
Human, Mouse, Rat
Details:
Rabbit IgG Polyclonal
Applications:
WB, ICC/IF
Catalog #
Availability
Size / Price
Qty
AF1590G-100UG
Bulk Order
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