PT-65
Tocris Bioscience, part of Bio-Techne | Catalog # 7651
Potent GSK3 Degrader (PROTAC®)
Product Description
PT-65 is a potent GSK3 Degrader (PROTAC®) (DC50 = 28.3 nM and 34.2 nM against GSK3α and GSK3β, respectively, in SH-SY5Y cells). It suppresses Okadaic acid (Cat. No. 1136) -induced tau hyperphosphorylation and ameliorates learning and memory impairments in rat models of Alzheimer's disease.GSK3β antibodies validated for Western Blot also available: Catalog # NBP1-47470 and AF2157.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
1082.19
Formula
C51H63N13O12S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-Amino-6-(4-((4-(4-(1-(17-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-3,6,9,12,15-pentaoxaheptadecyl)-1H-1,2,3-triazol-4-yl)butyl)piperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide
CAS Number
2721998-87-2
InChI Key
QJSFLEBIQZMJQF-UHFFFAOYSA-N
SMILES
O=C(NC=1C=NC=CC1)C=2N=C(C=NC2N)C3=CC=C(C=C3)S(=O)(=O)N4CCN(CC4)CCCCC=5N=NN(C5)CCOCCOCCOCCOCCOCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 108.22 | 100 |
Preparing Stock Solutions
for PT-65
The following data is based on the product molecular weight 1082.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.92 mL | 4.62 mL | 9.24 mL |
| 5 mM | 0.18 mL | 0.92 mL | 1.85 mL |
| 10 mM | 0.09 mL | 0.46 mL | 0.92 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.18 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Qu Discovery of PT-65 as a highly potent and selective proteolysis-targeting chimera degrader of GSK3 for treating Alzheimer's disease. Eur.J.Med.Chem. 2021 PMID: 34649182
Product Specific Notices for PT-65
For research use only
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