Okadaic acid

Name: Okadaic acid
Brand: Tocris Bioscience
SKU: 1136
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1136

(2)

Citations (126)

COA / SDS

Protein phosphatase 1 and 2A inhibitor

Key Product Details

Description:	Protein phosphatase 1 and 2A inhibitor
Chemical Name:	9,10-Deepithio-9,10-didehydroacanthifolicin
Purity:	≥90% (HPLC)
Molecular Weight:	805.01

View Full Technical Details for Okadaic acid

Technical Data
Citations / Reviews (2)

Biological Activity for Okadaic acid

Okadaic acid is a potent inhibitor of protein phosphatase 1 (IC₅₀ = 3 nM) and protein phosphatase 2A (IC₅₀ = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes.

Technical Data for Okadaic acid

M. Wt	805.01
Formula	C₄₄H₆₈O₁₃
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	78111-17-8
PubChem ID	90479758
InChi Key	QNDVLZJODHBUFM-WFXQOWMNSA-N
Smiles	[H][C@]1(CC(C)=C[C@@]2(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]2O)O1)[C@H](C)\C=C\[C@H]1CC[C@@]2(CC[C@@]3([H])O[C@]([H])([C@@H](O)C[C@H](C)[C@@]4([H])O[C@@]5(CCCCO5)CC[C@H]4C)C(=C)[C@@H](O)[C@]3([H])O2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Okadaic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40

Preparing Stock Solutions for Okadaic acid

The following data is based on the product molecular weight 805.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.48 mL	12.42 mL	24.84 mL
2.5 mM	0.50 mL	2.48 mL	4.97 mL
5 mM	0.25 mL	1.24 mL	2.48 mL
25 mM	0.05 mL	0.25 mL	0.50 mL

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Reconstitution Calculator

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References for Okadaic acid

References are publications that support the biological activity of the product.

Standaert Okadaic acid activates atypical protein kinase C (ζ/λ) in rat and 3T3/L1 adipocytes. J.Biol.Chem. 1999 PMID: 10318822
Nuydens Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 1998 PMID: 9489733
Haystead Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature 1989 PMID: 2562908
McCluskey Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem. 2002 PMID: 11881984
Cohen Okadaic acid: a new probe for the study of cellular regulation. TiBS 1990 PMID: 2158158