TCS 2002

Name: TCS 2002
Brand: Tocris Bioscience
SKU: 3869

Catalog # 3869 | Tocris Bioscience a Bio-Techne Brand

Citations (1)

COA / SDS

Potent GSK-3β inhibitor

Key Product Details

Description:	Potent GSK-3β inhibitor
Chemical Name:	2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole
Purity:	≥99% (HPLC)
Molecular Weight:	338.38

View Full Technical Details for TCS 2002

Technical Data
Citations (1) / Reviews

Biological Activity for TCS 2002

TCS 2002 is a potent inhibitor of GSK-3β (IC₅₀ = 35 nM). Oral adminstration inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain.

Compound Libraries for TCS 2002

TCS 2002 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TCS 2002

M. Wt	338.38
Formula	C₁₈H₁₄N₂O₃S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1005201-24-0
PubChem ID	24855958
InChi Key	RCKYSTKYIVULEK-UHFFFAOYSA-N
Smiles	O=S(C)C(C=C3)=CC=C3C2=COC1=CC=C(C4=NN=C(C)O4)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS 2002

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.84	100
	ethanol	8.46	25

Preparing Stock Solutions for TCS 2002

The following data is based on the product molecular weight 338.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.78 mL	29.55 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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Reconstitution Calculator

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References for TCS 2002

References are publications that support the biological activity of the product.

Saitoh 2-{3-[4-(alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β with good brain permeability. J.Med.Chem. 2009 PMID: 19775160

Citations for TCS 2002 (1)

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Citations are publications that use Bio-Techne products. Selected citations for TCS 2002 include:

Bellio et al. (2017) Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential. Sci Rep. 7:9702
PMID: 28851980

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