SB 415286
Tocris Bioscience, part of Bio-Techne | Catalog # 1617
Potent, selective GSK-3 inhibitor
Product Description
SB 415286 is a potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.Licensing Information
Sold for research purposes under agreement from GlaxoSmithKlineProduct Specifications
Molecular Weight
359.73
Formula
C16H10ClN3O5
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
CAS Number
264218-23-7
PubChem ID
4210951
InChI Key
PQCXVIPXISBFPN-UHFFFAOYSA-N
SMILES
OC1=C(Cl)C=C(NC2=C(C(=O)NC2=O)C2=C(C=CC=C2)[N+]([O-])=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.99 | 50 | |
| Ethanol | 8.99 | 25 |
Preparing Stock Solutions
for SB 415286
The following data is based on the product molecular weight 359.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.56 mL | 27.80 mL | 55.60 mL |
| 2.5 mM | 1.11 mL | 5.56 mL | 11.12 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.56 mL |
| 25 mM | 0.11 mL | 0.56 mL | 1.11 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cross Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J.Neurochem. 2001 PMID: 11279265
- Liang and Chuang Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. J.Biol.Chem. 2006 PMID: 17148450
- Coghlan Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem.Biol. 2000 PMID: 11033082
Product Specific Notices for SB 415286
For research use only
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