GluR1: Small Molecules and Peptides
GluR1 is a 4-transmembrane protein that belongs to the glutamate-gated ion channel family. It is one of four AMPA receptor subunits that form a functional heterotetrameric glutamate receptor. GluR1 only interacts with GluR2. In addition to constitutive phosphorylation on a key serine in the C-terminal extracellular region, neurotransmitter-induced phosphorylation of another key serine by CaMKII leads to a potentiation of glutamate-mediated current.
11 results for "GluR1 Small Molecules and Peptides" in Products
11 results for "GluR1 Small Molecules and Peptides" in Products
GluR1: Small Molecules and Peptides
GluR1 is a 4-transmembrane protein that belongs to the glutamate-gated ion channel family. It is one of four AMPA receptor subunits that form a functional heterotetrameric glutamate receptor. GluR1 only interacts with GluR2. In addition to constitutive phosphorylation on a key serine in the C-terminal extracellular region, neurotransmitter-induced phosphorylation of another key serine by CaMKII leads to a potentiation of glutamate-mediated current.
Potent AMPA antagonist; more selective than CNQX (Cat. No. 0190)
| Chemical Name: | 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of AMPA receptors; inhibits AMPA desensitization
| Chemical Name: | 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide |
| Purity: | ≥98% (HPLC) |
Broad spectrum glutamatergic antagonist
| Chemical Name: | 4-Hydroxyquinoline-2-carboxylic acid |
| Purity: | ≥98% (HPLC) |
AMPA agonist; also group I mGlu agonist
| Chemical Name: | (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid |
| Purity: | ≥99% (HPLC) |
Positive allosteric modulator of AMPA receptors
| Chemical Name: | N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide |
| Purity: | ≥98% (HPLC) |
Selective non-competitive AMPA antagonist
| Chemical Name: | 4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-benzenamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
Open-channel blocker of AMPA currents; selective for non-GluA2-containing receptors
| Chemical Name: | N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide |
| Purity: | ≥98% (HPLC) |
Selective positive allosteric modulator of AMPA receptors
| Chemical Name: | N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide |
| Purity: | ≥98% (HPLC) |
Competitive non-NMDA iGluR antagonist
| Alternate Names: | MPQX |
| Chemical Name: | [[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]phosphonic acid |
| Purity: | ≥98% (HPLC) |
GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors
| Alternate Names: | Topamax |
| Chemical Name: | 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate |
| Purity: | ≥98% (HPLC) |
Non-competitive non-NMDA iGluR antagonist
| Alternate Names: | GYKI 53773,LY 300164 |
| Chemical Name: | (8R)-7-Acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine |
| Purity: | ≥98% (HPLC) |
