IEM 1460
Tocris Bioscience, part of Bio-Techne | Catalog # 1636
Open-channel blocker of AMPA currents; selective for non-GluA2-containing receptors
Key Product Details
Description
Open-channel blocker of AMPA currents; selective for non-GluA2-containing receptors
Product Description
IEM 1460 is a voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca2+-permeable) receptors over GluA2-containing receptors (IC50 values are 2.6 and 1102 μM, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo.Product Specifications
Molecular Weight
454.33
Formula
C19H37N2Br.HBr
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N,N,H,-Trimethyl-5-[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]-1-pentanaminiumbromide hydrobromide
CAS Number
121034-89-7
PubChem ID
6604954
InChI Key
CQTDZUSQSTUZDA-UHFFFAOYSA-M
SMILES
[Br-].Br.C[N+](C)(C)CCCCCNCC12CC3CC(C1)CC(C2)C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 45.43 | 100 | |
| DMSO | 45.43 | 100 |
Preparing Stock Solutions
for IEM 1460
The following data is based on the product molecular weight 454.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.20 mL | 11.01 mL | 22.01 mL |
| 5 mM | 0.44 mL | 2.20 mL | 4.40 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.20 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schlesinger Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors. Br.J.Pharmacol. 2005 PMID: 15834439
- Gittis Selective inhibition of striatal fast-spiking interneurons causes dyskinesias. J.Neurosci. 2012 PMID: 22049415
- Buldakova Characterization of AMPA receptor populations in rat brain cells by the use of subunit-specific open channel blocking drug, IEM-1460. Brain Res. 1999 PMID: 10536213
Product Specific Notices for IEM 1460
For research use only
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