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Cyclothiazide

AMPA Receptor Modulators Small Molecule
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0713/10
0713/50

Key Product Details

Description: Positive allosteric modulator of AMPA receptors; inhibits AMPA desensitization
Chemical Name: 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide
Purity: ≥98% (HPLC)
Molecular Weight: 389.87

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Citations (21)

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  • Modulation of AMPA-receptor kinetics
    Name: Sergiy Sylantyev
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Cyclothiazide was used to prevent desensitization of AMPA-receptors in hippocampal pyramidal neurons. The compound prolonged the decay time of multi-synaptic evoked excitatory currents in cell somata. No difference between effects at 22-25 C and 33-36 C was detected. Illustration, grey trace: control response normalized to response amplitude under cyclothiazide.
    Preparation of 10 mM ethanol stock requires sonication.
    Cyclothiazide Serum 0713
  • effectively blocks desensitization of AMPA receptors
    Name: Karthik krishnamurthy
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: motor neurons
    Used to prevent desensitization AMPA receptors in motor neurons. Used at concentration of 200 micromolar to measure whole cell current in motor neurons upon AMPA application.
    Cyclothiazide Serum 0713

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