L-Quisqualic acid

Name: L-Quisqualic acid
Brand: Tocris Bioscience
SKU: 0188

Tocris Bioscience, part of Bio-Techne | Catalog # 0188

Citations (32)

COA / SDS

AMPA agonist; also group I mGlu agonist

Key Product Details

Description:	AMPA agonist; also group I mGlu agonist
Chemical Name:	(L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	189.13

View Full Technical Details for L-Quisqualic acid

Technical Data
Citations

Biological Activity for L-Quisqualic acid

L-Quisqualic acid is a glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. L-Quisqualic acid sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect).

Technical Data for L-Quisqualic acid

M. Wt	189.13
Formula	C₅H₇N₃O₅
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	52809-07-1
PubChem ID	40539
InChi Key	ASNFTDCKZKHJSW-REOHCLBHSA-N
Smiles	O=C1N(C[C@]([H])(N)C(O)=O)OC(N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-Quisqualic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	18.91	100
	water	1.89	10

Preparing Stock Solutions for L-Quisqualic acid

The following data is based on the product molecular weight 189.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.29 mL	26.44 mL	52.87 mL
5 mM	1.06 mL	5.29 mL	10.57 mL
10 mM	0.53 mL	2.64 mL	5.29 mL
50 mM	0.11 mL	0.53 mL	1.06 mL

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References for L-Quisqualic acid

References are publications that support the biological activity of the product.

Porter (S)-Homoquisqualate: a potent agonist at the glutamate metabotropic receptor. Br.J.Pharmacol. 1992 PMID: 1324071
Schulte Utilization of the resolved L-isomer of 2-amino-6-phosphohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 1994 PMID: 7953634
Littman Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus. Neuropharmacology 1995 PMID: 8532164