L-Quisqualic acid

Name: L-Quisqualic acid
Brand: Tocris Bioscience
SKU: 0188

Tocris Bioscience a Bio-Techne Brand

Catalog # 0188

Citations (9)

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Key Product Details

Description:	AMPA agonist; also group I mGlu agonist
Chemical Name:	(L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	189.13

View Full Technical Details for L-Quisqualic acid

Biological Activity for L-Quisqualic acid

L-Quisqualic acid is a glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. L-Quisqualic acid sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect).

Technical Data for L-Quisqualic acid

M. Wt	189.13
Formula	C₅H₇N₃O₅
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	52809-07-1
PubChem ID	40539
InChi Key	ASNFTDCKZKHJSW-REOHCLBHSA-N
Smiles	O=C1N(C[C@]([H])(N)C(O)=O)OC(N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-Quisqualic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	18.91	100
	water	1.89	10

Preparing Stock Solutions for L-Quisqualic acid

The following data is based on the product molecular weight 189.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.29 mL	26.44 mL	52.87 mL
5 mM	1.06 mL	5.29 mL	10.57 mL
10 mM	0.53 mL	2.64 mL	5.29 mL
50 mM	0.11 mL	0.53 mL	1.06 mL

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References for L-Quisqualic acid

References are publications that support the biological activity of the product.

Littman Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus. Neuropharmacology 1995 PMID: 8532164
Schulte Utilization of the resolved L-isomer of 2-amino-6-phosphohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 1994 PMID: 7953634
Porter (S)-Homoquisqualate: a potent agonist at the glutamate metabotropic receptor. Br.J.Pharmacol. 1992 PMID: 1324071

Citations for L-Quisqualic acid (9)

Showing 1 - 9 of 9 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for L-Quisqualic acid include:

Shin et al. (2018) Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo. Oncogenesis. 7:86
PMID: 30425240
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol. 13(4):372
PMID: 28135236
Mansari et al. (2015) Restoration of serotonin neuronal firing following long-term administration of bupr. but not parox. in olfactory bulbectomized rats. Int J Neuropsychopharmacol. 18
PMID: 25522394
Mansari et al. (2015) Effects of acute and sustained administration of Vort. on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Psychopharmacology (Berl). 232:2343
PMID: 25665528
Hu and Tu (2015) The roads to mitochondrial dysfunction in a rat model of posttraumatic syringomyelia. Biomed Res Int. 2015:831490
PMID: 25685811
Wall et al. (2014) Disruption of GRM1-mediated signalling using R.zole results in DNA damage in melanoma cells. Pigment Cell Melanoma Res. 27:263
PMID: 24330389
Porter et al. (2005) Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J Pharmacol Exp Ther. 315:711
PMID: 16040814
Calò et al. (2005) Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons. J Neurosci. 25:2245
PMID: 15745950
Ferré et al. (2002) Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function. Proc Natl Acad Sci U S A. 99:11940
PMID: 12189203

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Showing 1 - 9 of 9 citations Showing All

Product Documents for L-Quisqualic acid

COA

Certificate of Analysis

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