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AMPA Receptor Antagonists Small Molecule
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0373/10
0373/50

Key Product Details

Description: Potent AMPA antagonist; more selective than CNQX (Cat. No. 0190)
Chemical Name: 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide
Purity: ≥98% (HPLC)
Molecular Weight: 336.28

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Citations (180)

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Customer Reviews (3)

4.7 out of 5
3 customer ratings
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  • Partial block of AMPARs
    Name: Sergiy Sylantyev
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Cerebellar granule cell
    NBQX was used to block evoked AMPA-receptor response in outside-out membrane patches excised from hippocampal granule cells. 0.1 µM concentration caused an immediate partial block (see illustration). Highly specific and potent ligand, but requires long sonication to prepare 10 mM DMSO stock.Illustration: I - control AMPAR response at -60 mV cell membrane potential; II - control AMPAR response at +40 mV cell membrane potential; III - NBQX at -60 mV cell membrane potential; IV - NBQX at +40 mV cell membrane potential.
    NBQX Serum 0373
  • Inhibition of Synaptic Transmission in the VP
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    NBQX (5 mM)
    NBQX Serum 0373
  • an AMPA receptor antagonist
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    It is AMPA receptor antagonist. we used it at 30uM to block AMPA receptor in rat brain slice.

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