Key Product Details
Description: | Potent AMPA antagonist; more selective than CNQX (Cat. No. 0190) |
Chemical Name: | 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 336.28 |
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Citations for NBQX (180)
Citations are publications that use Bio-Techne products. Selected citations for NBQX include:
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Sabater et al.
(2021)
Voltage-gated potassium channels ensure action potential shape fidelity in distal axons.
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Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner
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Simultaneous voltage and calcium imaging and optogenetic stimulation with high sensitivity and a wide field of view.
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Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons.
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Kilohertz frame-rate two-photon tomography.
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Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
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Drd3 Signaling in the Lateral Septum Mediates Early Life Stress-Induced Social Dysfunction.
Neuron.
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AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation.
iScience.
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DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
Aging Cell.
16(6):1323
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Kashima and Grueter
(2017)
Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior.
Proc Natl Acad Sci U S A..
114(33):8865
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Amat
(2017)
Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice.
PLoS One.
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Wang et al.
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Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism.
J Clin Invest.
127:1978
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Delaney and Crane
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Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels.
Sci Rep.
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Dennis et al.
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Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
J Neurosci.
26:414
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Chen et al.
(2015)
AMPA Receptor-mTOR Activation is Required for the Antidepressant-Like Effects of Sarcosine during the Forced Swim Test in Rats: Insertion of AMPA Receptor may Play a Role.
Front Behav Neurosci.
9:162
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Grimes et al.
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A simple retinal mechanism contributes to perceptual interactions between rod- and cone-mediated responses in primates.
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Sheng et al.
(2015)
Involvement of adrenoceptors, DA receptors and AMPA receptors in antidepressant-like action of 7-O-ethylfangchinoline in mice.
Acta Pharmacol Sin.
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Pasca et al.
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Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
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Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice.
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Saunders et al.
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Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
Cereb Cortex.
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Hirono et al.
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BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.
Brain Res.
35:7082
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John et al.
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Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
J Neurosci.
1601:15
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Activation of corticostriatal circuitry relieves chronic neuropathic pain.
Physiol Rep.
35:5247
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Duménieu et al.
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Afterhyperpolarization (AHP) regulates the frequency and timing of action potentials in the mitral cells of the olfactory bulb: role of olfactory experience.
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Marciniak et al.
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The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory.
Front Synaptic Neurosci.
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Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3.
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Dual-channel circuit mapping reveals sensorimotor convergence in the primary motor cortex.
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NE Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.
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Tectal microcircuit generating visual selection commands on gaze-controlling neurons.
J Neurosci.
112:E1956
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Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.
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Mapelli et al.
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The effect of Dflu. on neuronal communication at a central synapse.
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Optical control of NMDA receptors with a diffusible photoswitch.
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Impact of subanesthetic doses of KA on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons.
Stroke.
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A novel mechanism for nicotinic potentiation of glutamatergic synapses.
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Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons.
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24:1247
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Fast retrieval and autonomous regulation of single spontaneously recycling synaptic vesicles.
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hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice.
Cell Stem Cell.
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Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator.
J Psychopharmacol.
28:935
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Cross-synaptic synchrony and transmission of signal and noise across the mouse retina.
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Repeated binge-like ethanol drinking alters ethanol drinking patterns and depresses striatal GABAergic transmission.
Neuropsychopharmacology.
39:579
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Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.
J Cereb Blood Flow Metab.
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CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
Nat Neurosci.
17:56
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Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA.
Nat Commun.
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Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function.
J Neurophysiol.
111:2493
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Ady et al.
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Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 δ glutamate receptors.
Proc Natl Acad Sci U S A.
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Varodayan and Harrison
(2014)
HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release.
J Neurosci.
7:89
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Wang and Mattson
(2014)
L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner.
Neurobiol Aging.
35:88
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Bonnet et al.
(2013)
AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis.
Ann Rheum Dis.
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Ufartes et al.
(2013)
Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice.
Hum Mol Genet.
22:2247
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Hou and Yu
(2013)
Activity-regulated somatostatin expression reduces dendritic spine density and lowers excitatory synaptic transmission via postsynaptic somatostatin receptor 4.
J Biol Chem.
288:2501
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Akrouh and Kerschensteiner
(2013)
Intersecting circuits generate precisely patterned retinal waves.
Neuron.
79:322
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Woo et al.
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The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development.
J Cell Biol.
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Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources.
Front Cell Neurosci.
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Alpert and
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Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons.
PLoS One.
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Protein tyrosine phosphatase α in the dorsomedial striatum promotes excessive ethanol-drinking behaviors.
Nat Neurosci.
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Proc Natl Acad Sci U S A.
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J Neurosci.
110:E1524
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S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis.
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J Neurosci.
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Physiological release of endogenous tau is stimulated by neuronal activity.
J Neuroimmunol.
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Koeglsperger et al.
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Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
Glia.
61:985
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Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.
Mol Med.
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Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
Mol Pharmacol.
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Heterogeneous reallocation of presynaptic efficacy in recurrent excitatory circuits adapting to inactivity.
Nat Neurosci.
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β-OE unmasks metabotropic receptor-mediated metaplasticity of NMDA receptor transmission in the female rat dentate gyrus.
Psychoneuroendocrinology.
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Mixed electrical-chemical transmission between hippocampal mossy fibers and pyramidal cells.
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Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
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Differential requirement for protein synthesis in presynaptic unmuting and muting in hippocampal glutamate terminals.
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Olfactory bulb glomerular NMDA receptors mediate olfactory nerve potentiation and odor preference learning in the neonate rat.
J Neurosci.
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Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth.
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Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus.
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Alteration of synaptic network dynamics by the intellectual disability protein PAK3.
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Nelson and Glitsch
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Quantal amplitude at the cone ribbon synapse can be adjusted by changes in cytosolic glutamate.
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An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
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Customer Reviews for NBQX (3)
Customer Images
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Species: RatAssay Type: In VitroCell Line/Tissue: Cerebellar granule cellNBQX was used to block evoked AMPA-receptor response in outside-out membrane patches excised from hippocampal granule cells. 0.1 µM concentration caused an immediate partial block (see illustration). Highly specific and potent ligand, but requires long sonication to prepare 10 mM DMSO stock.Illustration: I - control AMPAR response at -60 mV cell membrane potential; II - control AMPAR response at +40 mV cell membrane potential; III - NBQX at -60 mV cell membrane potential; IV - NBQX at +40 mV cell membrane potential.
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Species: MouseAssay Type: In VivoNBQX (5 mM)
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Species: RatAssay Type: Ex VivoIt is AMPA receptor antagonist. we used it at 30uM to block AMPA receptor in rat brain slice.
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