8-Hydroxy-DPAT hydrobromide
Tocris Bioscience a Bio-Techne Brand
Key Product Details
Description: | Selective 5-HT1A agonist; also has moderate affinity for 5-HT7 |
Alternative Names: | 8-OH-DPAT hydrobromide |
Chemical Name: | (±)-8-Hydroxy-2-dipropylaminotetralin hydrobromide |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 328.29 |
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Citations for 8-Hydroxy-DPAT hydrobromide (28)
Citations are publications that use Bio-Techne products. Selected citations for 8-Hydroxy-DPAT hydrobromide include:
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Gadgaard & Jensen
(2020)
Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay.
Biochem Pharmacol.
175
PMID: 32088264 -
Nguyen et al.
(2019)
Potentiation of the glycine response by serotonin on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.
Korean J Physiol Pharmacol.
23:271
PMID: 31297011 -
Walory et al.
(2018)
Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
Int J Mol Sci.
19
PMID: 30347827 -
Carvalho-Dias
(2017)
Serotonin regulates prostate growth through androgen receptor modulation.
Sci Rep.
7(1):15428
PMID: 29133842 -
Yin et al.
(2017)
Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron.
Cereb Cortex.
27:509
PMID: 26494800 -
Majeed et al.
(2016)
Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster.
Neural Plast.
2016:7291438
PMID: 26989517 -
Shelton et al.
(2015)
Selective pharmacological blockade of the 5-HT7 receptor attenuates light and 8-OH-DPAT induced phase shifts of mouse circadian wheel running activity.
Front Behav Neurosci.
8:453
PMID: 25642174 -
Watts et al.
(2015)
5-HT is a potent relaxant in rat superior mesenteric veins.
Invest Ophthalmol Vis Sci.
3:e00103
PMID: 25692021 -
Tullis et al.
(2015)
Sarpogrelate, a 5-HT2A Receptor Antagonist, Protects the Retina From Light-Induced Retinopathy.
Eur J Neurosci.
56:4560
PMID: 26200496 -
Richardson and Shelton
(2015)
N-MthD.-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas.
Cell Signal.
352:156
PMID: 25368340 -
Khatri et al.
(2014)
Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders.
Psychopharmacology (Berl).
231:1191
PMID: 23975037 -
McAllister et al.
(2014)
GPER1 stimulation alters posttranslational modification of RGSz1 and induces desensitization of 5-HT1A receptor signaling in the rat hypothalamus.
Neuroendocrinology.
100:228
PMID: 25402859 -
Bonchak et al.
(2014)
Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin.
Arch Biochem Biophys.
563:71
PMID: 25132642 -
Araragi et al.
(2013)
Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis.
Front Pharmacol.
4:97
PMID: 23935583 -
Fuss et al.
(2013)
Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long-term voluntary wheel running.
Synapse.
67:648
PMID: 23505009 -
Ishima et al.
(2012)
Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripipr.
Transl Psychiatry.
2:e170
PMID: 23047241 -
Borroto-Escuela et al.
(2012)
The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.
J Neurosci.
32:6295
PMID: 22553035 -
Rock et al.
(2012)
Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus.
Br J Pharmacol.
165:2620
PMID: 21827451 -
Murray et al.
(2011)
Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
J Neurophysiol.
106:925
PMID: 21653728 -
Rawls et al.
(2010)
5-HT(1A)-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians.
Neurosci Lett.
484:113
PMID: 20709144 -
Manzke et al.
(2010)
Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice.
J Clin Invest.
120:4118
PMID: 20978350 -
Hensler et al.
(2010)
Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice.
Psychoneuroendocrinology.
35:469
PMID: 19766402 -
Duncan et al.
(2010)
The effects of aging and chronic fluox. treatment on circadian rhythms and suprachiasmatic nucleus expression of neuropeptide genes and 5-HT1B receptors.
J Pharmacol Exp Ther.
31:1646
PMID: 20525077 -
Rossi et al.
(2010)
OE-induced desensitization of 5-HT1A receptor signaling in the paraventricular nucleus of the hypothalamus is independent of estrogen receptor-beta.
Psychoneuroendocrinology.
35:1023
PMID: 20138435 -
Manzke et al.
(2009)
Serotonin targets inhibitory synapses to induce modulation of network functions.
Philos Trans R Soc Lond B Biol Sci.
364:2589
PMID: 19651659 -
Müller et al.
(2009)
5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
PLoS One.
4:e6453
PMID: 19649285 -
Pagano et al.
(2008)
Gαo/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways.
J Neurosci.
20:1190
PMID: 18407463 -
Maciag et al.
(2006)
Evidence that the deficit in sexual behavior in adult rats neonatally exposed to cital. is a consequence of 5-HT1 receptor stimulation during development.
Brain Res.
1125:171
PMID: 17101120
There are no citations that match your criteria.
Customer Reviews for 8-Hydroxy-DPAT hydrobromide (1)
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Species: RatAssay Type: In Vivo5-HT1A/7 receptor (8-OHDPAT)(0.1 lmol/L)
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