8-Hydroxy-DPAT hydrobromide

Name: 8-Hydroxy-DPAT hydrobromide
Brand: Tocris Bioscience
SKU: 0529
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0529

(1)

Citations (6)

COA / SDS

Selective 5-HT1A agonist; also has moderate affinity for 5-HT7

Discontinued Product

0529 has been discontinued. View all 5-HT1 Receptor Agonists products.

Key Product Details

Description:	Selective 5-HT_1A agonist; also has moderate affinity for 5-HT₇
Alternative Names:	8-OH-DPAT hydrobromide
Chemical Name:	(±)-8-Hydroxy-2-dipropylaminotetralin hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	328.29

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Technical Data
Citations / Reviews (1)

Biological Activity for 8-Hydroxy-DPAT hydrobromide

The standard selective 5-HT_1A agonist. Also has moderate affinity for 5-HT₇ receptors (pK_i is 6.6 at the human 5-HT₇ receptor expressed in HEK 293 cells). Reduces hippocampal 5-HT levels following systemic administration in rats in vivo.

R-enantiomer and 7-Hydroxy Isomer also available..

Technical Data for 8-Hydroxy-DPAT hydrobromide

M. Wt	328.29
Formula	C₁₆H₂₅NO.HBr
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	76135-31-4
PubChem ID	6917794
InChi Key	BATPBOZTBNNDLN-UHFFFAOYSA-N
Smiles	Br.CCCN(CCC)C1CCC2=CC=CC(O)=C2C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for 8-Hydroxy-DPAT hydrobromide

References are publications that support the biological activity of the product.

Yoshitake and Kehr Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 2004 PMID: 15050424
Middlemiss 8-OH-DPAT discriminates between subtypes of the 5HT₁ recognition site. Eur.J.Pharmacol. 1983 PMID: 6223827
Wood Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT₇ receptor. Eur.J.Pharmacol. 2000 PMID: 10822046
Helton and Colbert Alteration of in-vitro 5-HT receptor pharmacology as a function of multiple treatment with 5-hydroxytryptamine of 8-hydroxy-2-(di-N-propylamino)tetralin in rat isolated aorta, uterus and fundus, and guinea pig isolated trachea. J.Pharm.Pharmacol. 1994 PMID: 7897596

8-Hydroxy-DPAT hydrobromide

Tocris Bioscience, part of Bio-Techne | Catalog # 0529

Key Product Details

Biological Activity for 8-Hydroxy-DPAT hydrobromide

Technical Data for 8-Hydroxy-DPAT hydrobromide

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Dilution Calculator

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References for 8-Hydroxy-DPAT hydrobromide

Product Documents for 8-Hydroxy-DPAT hydrobromide

COA

Certificate of Analysis

SDS

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