(R)-(+)-8-Hydroxy-DPAT hydrobromide

Name: ( R )-(+)-8-Hydroxy-DPAT hydrobromide
Brand: Tocris Bioscience
SKU: 1080
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1080

Citations (4)

(1)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Selective 5-HT_1A agonist; enantiomer of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529)
Chemical Name:	(2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	328.29

View Full Technical Details for (R)-(+)-8-Hydroxy-DPAT hydrobromide

Biological Activity for (R)-(+)-8-Hydroxy-DPAT hydrobromide

(R)-(+)-8-Hydroxy-DPAT hydrobromide is a full 5-HT_1A serotonin receptor agonist. Reduces hippocampal 5-HT levels following systemic administration in rats in vivo. More active enantiomer of 8-Hydroxy-DPAT hydrobromide.

Racemate and 7-Hydroxy Isomer also available.

Technical Data for (R)-(+)-8-Hydroxy-DPAT hydrobromide

M. Wt	328.29
Formula	C₁₆H₂₅NO.HBr
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	78095-19-9
PubChem ID	11957570
InChi Key	BATPBOZTBNNDLN-PFEQFJNWSA-N
Smiles	Br.CCCN(CCC)[C@@H]1CCC2=CC=CC(O)=C2C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-(+)-8-Hydroxy-DPAT hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	24.62	75
	DMSO	24.62	75

Preparing Stock Solutions for (R)-(+)-8-Hydroxy-DPAT hydrobromide

The following data is based on the product molecular weight 328.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	4.06 mL	20.31 mL	40.61 mL
3.75 mM	0.81 mL	4.06 mL	8.12 mL
7.5 mM	0.41 mL	2.03 mL	4.06 mL
37.5 mM	0.08 mL	0.41 mL	0.81 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for (R)-(+)-8-Hydroxy-DPAT hydrobromide

References are publications that support the biological activity of the product.

Yoshitake and Kehr Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 2004 PMID: 15050424
Corrfield Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogues at 5-hydroxytryptamine_1A receptors that are negatively coupled to adenylate cyclase. Mol.Pharmacol. 1991 PMID: 1828859
Bjork Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT_1A receptors in the brain. J.Med.Chem. 1989 PMID: 2522991

Citations for (R)-(+)-8-Hydroxy-DPAT hydrobromide (4)

Showing 1 - 4 of 4 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for (R)-(+)-8-Hydroxy-DPAT hydrobromide include:

Sadiq et al. (2019) 5-HT1A Receptor Function Makes Wound Healing a Happier Process. Front Pharmacol. 9:1406
PMID: 30618734
Cassilly et al. (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. Psychopharmacology (Berl). 11:e0154932
PMID: 27183222
Wierońska et al. (2015) The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies. Oncoscience. 232:259
PMID: 25012236
Rossi et al. (2008) Differential regulation of serotonin-1A receptor-stimulated [35S]GTP gamma S binding in the dorsal raphe nucleus by cital. and escital. Eur J Pharmacol. 583:103
PMID: 18289523

There are no citations that match your criteria.

Showing 1 - 4 of 4 citations Showing All

Customer Reviews for (R)-(+)-8-Hydroxy-DPAT hydrobromide (1)

5 out of 5

1 customer rating

5 stars

100%

4 stars

3 stars

2 stars

1 star

Customer Images

Showing 1 - 1 of 1 review Showing All

Filter By:

The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound

Name: Anonymous

Species: Other

Assay Type: In Vitro

Biologically active compounds that have been documented to interact with awide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat.# 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience

PMID: 27183222

There are no reviews that match your criteria.

Showing 1 - 1 of 1 review Showing All

Product Documents for (R)-(+)-8-Hydroxy-DPAT hydrobromide

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.