(R)-(+)-8-Hydroxy-DPAT hydrobromide

Name: ( R )-(+)-8-Hydroxy-DPAT hydrobromide
Brand: Tocris Bioscience
SKU: 1080
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1080

(1)

Citations (11)

COA / SDS

Selective 5-HT1A agonist; enantiomer of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529)

Discontinued Product

1080 has been discontinued. View all 5-HT1 Receptor Agonists products.

Key Product Details

Description:	Selective 5-HT_1A agonist; enantiomer of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529)
Chemical Name:	(2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	328.29

View Full Technical Details for (R)-(+)-8-Hydroxy-DPAT hydrobromide

Technical Data
Citations / Reviews (1)

Biological Activity for (R)-(+)-8-Hydroxy-DPAT hydrobromide

(R)-(+)-8-Hydroxy-DPAT hydrobromide is a full 5-HT_1A serotonin receptor agonist. Reduces hippocampal 5-HT levels following systemic administration in rats in vivo. More active enantiomer of 8-Hydroxy-DPAT hydrobromide.

Racemate and 7-Hydroxy Isomer also available.

Technical Data for (R)-(+)-8-Hydroxy-DPAT hydrobromide

M. Wt	328.29
Formula	C₁₆H₂₅NO.HBr
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	78095-19-9
PubChem ID	11957570
InChi Key	BATPBOZTBNNDLN-PFEQFJNWSA-N
Smiles	Br.CCCN(CCC)[C@@H]1CCC2=CC=CC(O)=C2C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for (R)-(+)-8-Hydroxy-DPAT hydrobromide

References are publications that support the biological activity of the product.

Corrfield Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogues at 5-hydroxytryptamine_1A receptors that are negatively coupled to adenylate cyclase. Mol.Pharmacol. 1991 PMID: 1828859
Yoshitake and Kehr Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 2004 PMID: 15050424
Bjork Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT_1A receptors in the brain. J.Med.Chem. 1989 PMID: 2522991

(R)-(+)-8-Hydroxy-DPAT hydrobromide

Tocris Bioscience, part of Bio-Techne | Catalog # 1080

Key Product Details

Biological Activity for (R)-(+)-8-Hydroxy-DPAT hydrobromide

Technical Data for (R)-(+)-8-Hydroxy-DPAT hydrobromide

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References for (R)-(+)-8-Hydroxy-DPAT hydrobromide

Product Documents for (R)-(+)-8-Hydroxy-DPAT hydrobromide

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Certificate of Analysis

SDS

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