NBQX disodium salt

Name: NBQX disodium salt
Brand: Tocris Bioscience
SKU: 1044
Rating: 5 (2 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 1044

Citations (41)

(2)

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Key Product Details

Description:	Potent AMPA antagonist; more water soluble form of NBQX (Cat. No. 0373)
Chemical Name:	2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	380.24

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Biological Activity for NBQX disodium salt

NBQX disodium salt is a selective and competitive AMPA and kainate receptor antagonist (IC₅₀ = 0.15 μM and 4.8 μM, respectively). NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529), decreases mTOR and BDNF levels. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo.

NBQX disodium salt is a more water-soluble form of NBQX (Cat. No. 0373).

Licensing Information

Sold with the permission of Novo Nordisk A/S

Technical Data for NBQX disodium salt

M. Wt	380.24
Formula	C₁₂H₆N₄O₆SNa₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	479347-86-9
PubChem ID	3272523
InChi Key	SVJKYIUJRJEABK-UHFFFAOYSA-L
Smiles	[Na+].[Na+].NS(=O)(=O)C1=C2C(=CC=C1)C1=NC([O-])=C([O-])N=C1C=C2[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NBQX disodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	38.02	100

Preparing Stock Solutions for NBQX disodium salt

The following data is based on the product molecular weight 380.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.63 mL	13.15 mL	26.30 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
10 mM	0.26 mL	1.31 mL	2.63 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for NBQX disodium salt

References are publications that support the biological activity of the product.

Yoon Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test J.Korean Med.Sci. 2005 PMID: 15832006
Namba Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 1994 PMID: 8199874
Sheardown The pharmacology of AMPA receptors and their antagonists. Stroke 1993 PMID: 7504337
Gill The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res. 1992 PMID: 1504814
Zeman and Lodg Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro. Br.J.Pharmacol. 1992 PMID: 1382781

Citations for NBQX disodium salt (41)

Showing 1 - 10 of 41 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for NBQX disodium salt include:

Maldonado et al. (2021) Oxytocin shapes spontaneous activity patterns in the developing visual cortex by activating somatostatin interneurons. Curr Biol. 31:322
PMID: 33157028
O'Malley et al. (2020) TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations J Neurosci. 40:4813
PMID: 32414784
Kramer et al. (2020) Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release. ELife. 9
PMID: 32870779
Bocchio et al. (2020) Hippocampal hub neurons maintain distinct connectivity throughout their lifetime. Nat Commun. 11:4559
PMID: 32917906
Evans et al. (2020) Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons. Cell Rep. 32
PMID: 32937133
Kiritoshi and Neugebauer (2018) Pathway-specific alterations of cortico-amygdala transmission in an arthritis pain model. ACS Chem Neurosci. 9:2252
PMID: 29630339
Xiao et al. (2018) OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons. Elife. 7
PMID: 29676731
Purkey et al. (2018) AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca²⁺-Permeable AMPA Receptors to Control LTP. Cell Rep. 25:974
PMID: 30355502
Fan et al. (2018) All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition. Nat Methods. 15:823
PMID: 30275587
Chang and Higley (2018) Potassium channels contribute to activity-dependent regulation of dendritic inhibition. Physiol Rep. 6:e13747
PMID: 29939492
Maeder et al. (2018) The THO Complex Coordinates Transcripts for Synapse Development and DA Neuron Survival. Cell. 174:1436
PMID: 30146163
Sancho and Bloodgood (2018) Functional Distinctions between Spine and Dendritic Synapses Made onto Parvalbumin-Positive Interneurons in Mouse Cortex. Cell Rep. 24:2075
PMID: 30134169
Beas et al. (2018) The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism. Nat Neurosci. 21:963
PMID: 29915192
Collins et al. (2018) Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei. Neuron. 98:366
PMID: 29628187
Lai et al. (2017) Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18. Neuron. 95:591
PMID: 28772123
Sigler et al. (2017) Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release. Neuron. 94:304
PMID: 28426965
Tikidji-Hamburyan et al. (2017) Rods progressively escape saturation to drive visual responses in daylight conditions. Nat Commun. 8:1813
PMID: 29180667
Kim and Cho (2017) Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala. Neuron. 95:1129
PMID: 28823727
Xiao et al. (2017) Biased OXTergic Modulation of Midbrain DA Systems. Neuron. 95:368
PMID: 28669546
Li et al. (2017) A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex. Neuron. 94:1155
PMID: 28641114
Hull (2017) Measuring Feedforward Inhibition and Its Impact on Local Circuit Function. Cold Spring Harb Protoc. 2017
PMID: 28461661
Liu et al. (2016) Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour. Nature. 538:383
PMID: 27732573
O'Donnell et al. (2016) Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. J Neurosci. 36:7109
PMID: 27383588
Tsutsui-Kimura et al. (2015) Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex. Neuron. 18
PMID: 25522418
Liu et al. (2015) Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output. Sci Rep. 35:5680
PMID: 25855181
Malvaez et al. (2015) Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions. PLoS One. 5:12511
PMID: 26212790
Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. Neurochem Int. 10:e0131430
PMID: 26102354
Reinhard et al. (2014) Step-by-step instructions for retina recordings with perforated multi electrode arrays. PLoS One. 9:e106148
PMID: 25165854
Crook et al. (2014) A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina. Vis Neurosci. 31:57
PMID: 24801624
Bortone et al. (2014) Translaminar inhibitory cells recruited by layer 6 corticothalamic neurons suppress visual cortex. J Neurosci. 82:474
PMID: 24656931
Bloodgood et al. (2013) The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. Nature. 503:121
PMID: 24201284
He et al. (2013) Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-MthD.-aspartate receptor inhibition. Int J Neuropsychopharmacol. 109:1535
PMID: 23255721
Butti et al. (2012) Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. Brain. 135:3320
PMID: 23008234
Olsen et al. (2012) Gain control by layer six in cortical circuits of vision. J Neurophysiol. 483:47
PMID: 22367547
Gensel et al. (2012) Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury. J Neurosci. 7:e33519
PMID: 22428066
Carlson et al. (2012) Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica. Brain Behav. 2:391
PMID: 22950043
Zheng et al. (2010) SAP102 is a highly mobile MAGUK in spines. J Neurosci. 30:4757
PMID: 20357126
Shin et al. (2006) Vasoconstrictive neurovascular coupling during focal ischemic depolarizations. J Cereb Blood Flow Metab. 26:1018
PMID: 16340958
Liu et al. (2004) Astrocyte-mediated activation of neuronal kainate receptors. Nature. 101:3172
PMID: 14766987
Harkany et al. (2004) Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3. PLoS One. 24:4978
PMID: 15163690
Ronesi et al. (2004) Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport. J Neurosci. 24:1673
PMID: 14973237

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The best option to block AMPA receptors

Name: Luiz Alexandre Magno

Species: Mouse

Assay Type: In Vivo

I infused the NBQX disodium salt (22 mM) into mouse brain to block AMPA receptors in the striatum. This was done by using an internal infusion cannula. The disodium salt is the best choice for this kind of experiment because it is soluble in aqueous solutions such as NaCl 0.9%. NBQX is more specific and potent than DNQX.

Always make fresh solutions

PMID: 28436980
Excellent AMPA receptor antagonist

Name: Andy Gao

Species: Mouse

Assay Type: In Vitro

Cell Line/Tissue: Hippocampus

Used in extracellular bath solution during electrophysiology of hippocampal neuron culture to block glutamatergic AMPA receptors to isolate NMDA receptor currents.

Aliquot properly in dMSO

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