NBQX disodium salt is a selective and competitive AMPA and kainate receptor antagonist (IC₅₀ = 0.15 μM and 4.8 μM, respectively). NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529), decreases mTOR and BDNF levels. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo.

NBQX disodium salt is a more water-soluble form of NBQX (Cat. No. 0373).

Licensing Information

Sold with the permission of Novo Nordisk A/S

Product Specifications

Molecular Weight

380.24

Formula

C₁₂H₆N₄O₆SNa₂

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt

CAS Number

479347-86-9

PubChem ID

3272523

InChI Key

SVJKYIUJRJEABK-UHFFFAOYSA-L

SMILES

[Na+].[Na+].NS(=O)(=O)C1=C2C(=CC=C1)C1=NC([O-])=C([O-])N=C1C=C2[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	19.01	50

Preparing Stock Solutions for NBQX disodium salt

The following data is based on the product molecular weight 380.24

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.26 mL	26.30 mL	52.60 mL
2.5 mM	1.05 mL	5.26 mL	10.52 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
25 mM	0.11 mL	0.53 mL	1.05 mL

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Background References

References are publications that support the biological activity of the product.

Zeman and Lodg Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro. Br.J.Pharmacol. 1992 PMID: 1382781
Namba Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 1994 PMID: 8199874
Sheardown The pharmacology of AMPA receptors and their antagonists. Stroke 1993 PMID: 7504337
Gill The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res. 1992 PMID: 1504814

NBQX disodium salt

Tocris Bioscience, part of Bio-Techne | Catalog # 1044

Key Product Details

Description

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Product Description