NBQX disodium salt

Name: NBQX disodium salt
Brand: Tocris Bioscience
SKU: 1044
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1044

(3)

Citations (266)

COA / SDS

Potent AMPA antagonist; more water soluble form of NBQX (Cat. No. 0373)

Key Product Details

Description:	Potent AMPA antagonist; more water soluble form of NBQX (Cat. No. 0373)
Chemical Name:	2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	380.24

View Full Technical Details for NBQX disodium salt

Technical Data
Citations / Reviews (3)

Biological Activity for NBQX disodium salt

NBQX disodium salt is a selective and competitive AMPA and kainate receptor antagonist (IC₅₀ = 0.15 μM and 4.8 μM, respectively). NBQX blocks the antidepressant effects of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529), decreases mTOR and BDNF levels. NBQX is neuroprotective, anticonvulsant, antinociceptive and active in vivo.

NBQX disodium salt is a more water-soluble form of NBQX (Cat. No. 0373).

Licensing Information

Sold with the permission of Novo Nordisk A/S

Technical Data for NBQX disodium salt

M. Wt	380.24
Formula	C₁₂H₆N₄O₆SNa₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	479347-86-9
PubChem ID	3272523
InChi Key	SVJKYIUJRJEABK-UHFFFAOYSA-L
Smiles	[Na+].[Na+].NS(=O)(=O)C1=C2C(=CC=C1)C1=NC([O-])=C([O-])N=C1C=C2[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NBQX disodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	38.02	100

Preparing Stock Solutions for NBQX disodium salt

The following data is based on the product molecular weight 380.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.63 mL	13.15 mL	26.30 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
10 mM	0.26 mL	1.31 mL	2.63 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for NBQX disodium salt

References are publications that support the biological activity of the product.

Yoon Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test J.Korean Med.Sci. 2005 PMID: 15832006
Zeman and Lodg Pharmacological characterization of non-NMDA subtypes of glutamate receptors in the neonatal rat hemisected spinal cord in vitro. Br.J.Pharmacol. 1992 PMID: 1382781
Namba Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy. Brain Res. 1994 PMID: 8199874
Sheardown The pharmacology of AMPA receptors and their antagonists. Stroke 1993 PMID: 7504337
Gill The neuroprotective actions of 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX) in a rat focal ischaemia model. Brain Res. 1992 PMID: 1504814