ZK 200775

Name: ZK 200775
Brand: Tocris Bioscience
SKU: 2345

Tocris Bioscience, part of Bio-Techne | Catalog # 2345

Citations (22)

COA / SDS

Competitive non-NMDA iGluR antagonist

Key Product Details

Description:	Competitive non-NMDA iGluR antagonist
Alternative Names:	MPQX
Chemical Name:	[[3,4-Dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]phosphonic acid
Purity:	≥98% (HPLC)
Molecular Weight:	409.25

View Full Technical Details for ZK 200775

Technical Data
Citations

Biological Activity for ZK 200775

ZK 200775 is a competitive AMPA/kainate antagonist. In rat cortical membranes, displays high affinity for [³H]-AMPA (K_i = 120 nM) and [³H]-CNQX (K_i = 32 nM) binding sites and low affinity for kainate and NMDA channel-associated binding sites (IC₅₀ values range from 2.5 to 11 μM). Inhibits currents induced by AMPA, Kainate and NMDA with IC₅₀ values of 21 nM, 27 nM, and > 1 μM respectively. Displays anxiolytic, anticonvulsant and muscle relaxant activity in vivo.

Compound Libraries for ZK 200775

ZK 200775 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ZK 200775

M. Wt	409.25
Formula	C₁₄H₁₅N₃O₆F₃P
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	161605-73-8
PubChem ID	208953
InChi Key	WZMQMKNCWDCCMT-UHFFFAOYSA-N
Smiles	OP(O)(=O)CN1C(=O)C(=O)NC2=CC(=C(C=C12)N1CCOCC1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZK 200775

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.93	100
	ethanol	20.46	50

Preparing Stock Solutions for ZK 200775

The following data is based on the product molecular weight 409.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.22 mL	24.43 mL
5 mM	0.49 mL	2.44 mL	4.89 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for ZK 200775

References are publications that support the biological activity of the product.

Sobolevsky X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature 2009 PMID: 19946266
Turski ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauman Proc.Natl.Acad.Sci.USA.
Kosowski Nicotine-induced DA release in the nucleus accumbens is inhibited by the novel AMPA antagonist ZK200775 and the NMDA antagonist CGP39551n Pychopharmacology
Elger Novel α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor antagonists of 2,3-benzodiazepine type: chemical synthesis, in vitro characterization, and in vivo prevention of acute neurodegeneration. J.Med.Chem. 2005 PMID: 15999999