Key Product Details
Description: | Selective NMDA agonist |
Chemical Name: | N-Methyl-D-aspartic acid |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 147.13 |
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Citations for NMDA (91)
Citations are publications that use Bio-Techne products. Selected citations for NMDA include:
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Spitzer et al.
(2019)
Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age.
Neuron.
101:459
PMID: 30654924 -
McIver et al.
(2019)
Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons.
Cell Rep.
28:992
PMID: 31340159 -
Cortés-Montero et al.
(2019)
The axonal motor neuropathy-related HINT1 protein is a zinc- and calmodulin-regulated cysteine SUMO protease.
Antioxid Redox Signal.
2019;
PMID: 31088288 -
Lozovaya et al.
(2018)
GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.
Nat Commun.
9(1):1422
PMID: 29651049 -
Rodríguez-Muñoz et al.
(2018)
Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors.
Oncotarget.
9:23373
PMID: 29805740 -
Rodríguez-Muñoz et al.
(2018)
Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
Mol Brain.
11:51
PMID: 30223868 -
Lim et al.
(2018)
Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures.
Int J Mol Sci.
19
PMID: 30274399 -
Sharifi
(2017)
The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental areamediate morphine-induced memory consolidation impairment.
Neuroscience.
353:7
PMID: 28412500 -
Reinhard et al.
(2016)
The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory.
Nat Commun.
7:11613
PMID: 27194588 -
O'Donnell et al.
(2016)
Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes.
J Neurosci.
36:7109
PMID: 27383588 -
Pigott and Garthwaite
(2016)
Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus.
Front Synaptic Neurosci.
8:17
PMID: 27445786 -
Rodríguez-Muñoz et al.
(2015)
The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
Oncotarget.
6:35458
PMID: 26461475 -
Eckel et al.
(2015)
Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity.
Neuropharmacology.
88:82
PMID: 25245802 -
Bell et al.
(2015)
Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.
Nat Commun.
6:7066
PMID: 25967870 -
Bertrand et al.
(2015)
Conformations of tissue plasminogen activator (tPA) orchestrate neuronal survival by a crosstalk between EGFR and NMDAR.
Cell Death Dis.
6:e1924
PMID: 26469972 -
Curcio et al.
(2015)
Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
Cell Death Dis.
6:e1645
PMID: 25675305 -
Garthwaite et al.
(2015)
Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
Glia.
63:383
PMID: 25327839 -
Iskandrani et al.
(2015)
Impact of subanesthetic doses of KA on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons.
J Psychopharmacol.
29:792
PMID: 25759403 -
Grosso et al.
(2015)
The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli.
Nat Commun.
6:8886
PMID: 26619940 -
An et al.
(2014)
Neuritin can normalize neural deficits of Alzheimer's disease.
Cell Death Dis.
5:e1523
PMID: 25393479 -
Chen et al.
(2014)
Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction.
Nat Commun.
5:5331
PMID: 25354791 -
Thein et al.
(2014)
IKK regulates the deubiquitinase CYLD at the postsynaptic density.
Biochem Biophys Res Commun.
450:550
PMID: 24928390 -
Aligny et al.
(2014)
KA alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP mice.
Cell Death Dis.
5:e1311
PMID: 24991763 -
Hsu et al.
(2014)
STAT1 negatively regulates spatial memory formation and mediates the memory-impairing effect of Aβ.
Neuropsychopharmacology.
39:746
PMID: 24081304 -
Lee et al.
(2014)
Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
Philos Trans R Soc Lond B Biol Sci.
369:20130158
PMID: 24298159 -
Thein et al.
(2014)
CaMKII mediates recruitment and activation of the deubiquitinase CYLD at the postsynaptic density.
PLoS One.
9:e91312
PMID: 24614225 -
Sánchez-Blázquez et al.
(2014)
The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Int J Neuropsychopharmacol.
17:1943
PMID: 24485144 -
Antoniou et al.
(2014)
PICK1 links Argonaute 2 to endosomes in neuronal dendrites and regulates miRNA activity.
EMBO Rep.
15:548
PMID: 24723684 -
Fan et al.
(2014)
Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation.
Nat Neurosci.
17:471
PMID: 24464042 -
Yang et al.
(2013)
Camkii-mediated phosphorylation regulates distributions of Syngap-α1 and -α2 at the postsynaptic density.
PLoS One.
8:e71795
PMID: 23967245 -
Pigott et al.
(2013)
On the selectivity of neuronal NOS inhibitors.
Br J Pharmacol.
168:1255
PMID: 23072468 -
Kung et al.
(2013)
Evidence for glutamate as a neuroglial transmitter within sensory ganglia.
PLoS One.
8:e68312
PMID: 23844184 -
Vicente-Sánchez et al.
(2013)
HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
Mol Brain.
6:42
PMID: 24093505 -
Tupone et al.
(2013)
Central activation of the A1 adenosine receptor (A1AR) induces a hypothermic, torpor-like state in the rat.
J Neurosci.
33:14512
PMID: 24005302 -
Selvakumar et al.
(2013)
S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis.
Proc Natl Acad Sci U S A.
110:1077
PMID: 23277581 -
Pooler et al.
(2013)
Physiological release of endogenous tau is stimulated by neuronal activity.
EMBO Rep.
14:389
PMID: 23412472 -
Siddoway et al.
(2013)
An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
J Neurosci.
33:11206
PMID: 23825423 -
Fairless et al.
(2013)
Membrane potential measurements of isolated neurons using a voltage-sensitive dye.
PLoS One.
8:e58260
PMID: 23516458 -
Rojas et al.
(2013)
Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
Mol Pharmacol.
83:106
PMID: 23066089 -
Rodríguez-Muñoz et al.
(2012)
The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.
Neuropsychopharmacology.
37:338
PMID: 21814188 -
Wang et al.
(2012)
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
J Neurosci.
32:9773
PMID: 22815492 -
Huang et al.
(2012)
Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds.
PLoS One.
7:e30662
PMID: 22292013 -
Hedegaard et al.
(2012)
Molecular pharmacology of human NMDA receptors.
Neurochem Int.
61:601
PMID: 22197913 -
Cassé et al.
(2012)
Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals.
J Neurosci.
32:5186
PMID: 22496564 -
Tallarida et al.
(2012)
Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay.
Amino Acids.
42:2521
PMID: 21850438 -
Cunningham et al.
(2012)
Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance.
Epilepsia.
53:1205
PMID: 22686654 -
Bahia et al.
(2012)
Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity.
J Neurochem.
123:182
PMID: 22804756 -
He et al.
(2012)
Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons.
FASEB J.
26:334
PMID: 21982949 -
Owaisat et al.
(2012)
In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.
Neurosci Lett.
525:12
PMID: 22877698 -
Udagawa et al.
(2012)
Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
Mol Cell.
47:253
PMID: 22727665 -
Niwa et al.
(2012)
Gephyrin-independent GABA(A)R mobility and clustering during plasticity.
PLoS One.
7:e36148
PMID: 22563445 -
Beard et al.
(2012)
Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of β-catenin in response to homocysteine.
Vascul Pharmacol.
56:159
PMID: 22285407 -
Wang and Green
(2011)
Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro.
J Neurosci.
31:7938
PMID: 21613508 -
Yang et al.
(2011)
SynGAP moves out of the core of the postsynaptic density upon depolarization.
Neuroscience.
192:132
PMID: 21736925 -
Ali
(2011)
CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
J Neurophysiol.
105:1051
PMID: 21123660 -
Li et al.
(2011)
Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages.
J Neuroinflammation.
8:15
PMID: 21324129 -
Fontainhas et al.
(2011)
Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission.
PLoS One.
6:e15973
PMID: 21283568 -
Meissirel et al.
(2011)
VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation.
Proc Natl Acad Sci U S A.
108:13782
PMID: 21804034 -
Mahajan et al.
(2011)
Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.
Neuroscience.
189:305
PMID: 21620933 -
Lussier et al.
(2011)
Activity-dependent ubiquitination of the AMPA receptor subunit GluA2.
J Neurosci.
31:3077
PMID: 21414928 -
Maier et al.
(2010)
Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
J Biol Chem.
285:35606
PMID: 20826795 -
Marignier et al.
(2010)
Oligodendrocytes are damaged by neuromyelitis optica immunoglobulin G via astrocyte injury.
Brain.
133:2578
PMID: 20688809 -
Baron et al.
(2010)
NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity.
Cell Death Differ.
17:860
PMID: 19911010 -
Pansiot et al.
(2010)
Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat.
PLoS One.
5:e10916
PMID: 20532231 -
Citri et al.
(2010)
Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.
J Neurosci.
30:16437
PMID: 21147983 -
Roselli et al.
(2009)
Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
PLoS One.
4:e6011
PMID: 19547699 -
Citri et al.
(2009)
N-MthD.-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system.
Eur J Neurosci.
30:1443
PMID: 19821836 -
Iwasato et al.
(2008)
Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.
J Neurosci.
28:5931
PMID: 18524897 -
Furness et al.
(2008)
A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2).
Neuroscience.
157:80
PMID: 18805467 -
Wayman et al.
(2008)
An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
Proc Natl Acad Sci U S A.
105:9093
PMID: 18577589 -
Iida et al.
(2007)
Synaptic scaffolding molecule alpha is a scaffold to mediate N-MthD.-aspartate receptor-dependent RhoA activation in dendrites.
Mol Cell Biol.
27:4388
PMID: 17438139 -
Davidkova and Carroll
(2007)
Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus.
J Neurosci.
27:13273
PMID: 18045921 -
Ziskin et al.
(2007)
Vesicular release of glutamate from unmyelinated axons in white matter.
Nat Neurosci.
10:321
PMID: 17293857 -
Sossa et al.
(2007)
AMPAR exocytosis through NO modulation of PICK1.
Neuropharmacology.
53:92
PMID: 17555774 -
Holman et al.
(2007)
Differential redistribution of native AMPA receptor complexes following LTD induction in acute hippocampal slices.
Neuropharmacology.
52:92
PMID: 16815481 -
Marsden et al.
(2007)
NMDA receptor activation potentiates inhibitory transmission through GABA receptor-associated protein-dependent exocytosis of GABA(A) receptors.
J Neurosci.
27:14326
PMID: 18160640 -
Proudfoot et al.
(2006)
Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain.
Curr Biol.
16:1591
PMID: 16920620 -
Smith et al.
(2006)
cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein.
J Neurosci.
26:2391
PMID: 16510716 -
Jiang et al.
(2006)
Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism.
J Neurosci.
26:4318
PMID: 16624952 -
Lesne et al.
(2005)
Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity.
J Biol Chem.
280:24941
PMID: 15797869 -
Lea et al.
(2005)
Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.
Br J Pharmacol.
145:527
PMID: 15821750 -
Nakayama et al.
(2005)
Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses.
J Neurosci.
25:4040
PMID: 15843606 -
Yang et al.
(2005)
Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
J Neurosci.
25:4288
PMID: 15858055 -
Lenz and Avruch
(2005)
Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
J Biol Chem.
280:38121
PMID: 16183639 -
Srinivasan et al.
(2004)
Cell type-specific interleukin-1beta signaling in the CNS.
J Neurosci.
24:6482
PMID: 15269258 -
Kurata et al.
(2004)
beta-OE, dehydroepiandrosterone, and dehydroepiandrosterone sulfate protect against N-MthD.-aspartate-induced neurotoxicity in rat hippocampal neurons by different mechanisms.
J Pharmacol Exp Ther.
311:237
PMID: 15175425 -
Morante-Oria et al.
(2003)
Subpallial origin of a population of projecting pioneer neurons during corticogenesis.
Proc Natl Acad Sci U S A.
100:12468
PMID: 14523241 -
O'Leary et al.
(2000)
Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism.
Br J Pharmacol.
131:1429
PMID: 11090117 -
Casado et al.
(2000)
Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse.
Proc Natl Acad Sci U S A.
97:11593
PMID: 11016958 -
Rundfeldt
(2000)
Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels.
Arzneimittelforschung.
50:1063
PMID: 11190770 -
Fedele et al.
(1996)
In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
Br J Pharmacol.
119:590
PMID: 8894183
There are no citations that match your criteria.
Customer Reviews for NMDA (4)
Customer Images
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Species: RatAssay Type: In VitroCell Line/Tissue: spinal cord neuronsFor calcium imaging in motor neurons and other spinal neurons. 50 micromolar was used to stimulate neuronal cultures for 90 seconds. Time course of cytosolic calcium influx was measured using ratiometric calcium indicator Fura2-AM.
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Species: MouseAssay Type: In VivoCell Line/Tissue: neurons25uM
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Species: RatAssay Type: In VitroCell Line/Tissue: Sprague-Dawley rats primary neuronaltreat 50 μM NMDA for 10 min
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Species: RatAssay Type: In VitroCell Line/Tissue: HippocampusMixture of 100 microM of glycine + 100 microM NMDA was used to evoke an NMDA receptor response without contamination from other glutamate receptors in outside-out patched excised from hippocampal neurons. NMDA displayed a clear agonist effect, as expected. Easily soluble, no problem if stored in frozen aliquots for more than half a year.Should be used instead of glutamate for selective activation of NMDA receptors
There are no reviews that match your criteria.