MNI-caged-NMDA

Name: MNI-caged-NMDA
Brand: Tocris Bioscience
SKU: 2224

Tocris Bioscience a Bio-Techne Brand

Catalog # 2224

Citations (1)

COA / SDS

Discontinued Product

2224 has been discontinued. View all Additional NMDA Receptor Compounds products.

Key Product Details

Description:	Caged NMDA
Alternative Names:	4-Methoxy-7-nitroindolinyl-caged N-methyl-D-aspartic acid
Chemical Name:	(R)-α-Methylamino-2,3-dihydro-4-methoxy-7-nitro-γ-oxo-1H-indole-1-butanoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	323.3

View Full Technical Details for MNI-caged-NMDA

Biological Activity for MNI-caged-NMDA

MNI-caged-NMDA is a NMDA (Cat.No. 0114) caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Stoichiometrically releases chirally pure NMDA. Suitable for uncaging with 300-380 nm excitation. Improved localization can be achieved by uncaging at 405 nm (with mM concentration of caged compound in the bath solution). Exhibits rapid uncaging rate relative to ionotropic glutamate receptor activation.

Licensing Information

Sold under license from the UK Medical Research Council

Technical Data for MNI-caged-NMDA

M. Wt	323.3
Formula	C₁₄H₁₇N₃O₆
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1227675-52-6
PubChem ID	57369294
InChi Key	MUCRWOILMOHLGD-SECBINFHSA-N
Smiles	O=C(C[C@H](C(O)=O)NC)N2C1=C([N+]([O-])=O)C=CC(OC)=C1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MNI-caged-NMDA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	1.62	5 with gentle warming
	DMSO	32.33	100

Preparing Stock Solutions for MNI-caged-NMDA

The following data is based on the product molecular weight 323.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.09 mL	15.47 mL	30.93 mL
5 mM	0.62 mL	3.09 mL	6.19 mL
10 mM	0.31 mL	1.55 mL	3.09 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for MNI-caged-NMDA

References are publications that support the biological activity of the product.

Palma-Cerda New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups. Neuropharmacology. 2012 PMID: 22609535

Citations for MNI-caged-NMDA (1)

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Citations are publications that use Bio-Techne products. Selected citations for MNI-caged-NMDA include:

Zhang et al. (2016) Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors. Nat.Commun.. 7:12650
PMID: 27586999

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