Kynurenic acid

Name: Kynurenic acid
Brand: Tocris Bioscience
SKU: 0223

Tocris Bioscience, part of Bio-Techne | Catalog # 0223

Citations (186)

COA / SDS

Broad spectrum glutamatergic antagonist

Key Product Details

Description:	Broad spectrum glutamatergic antagonist
Chemical Name:	4-Hydroxyquinoline-2-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	189.17

View Full Technical Details for Kynurenic acid

Technical Data
Citations

Biological Activity for Kynurenic acid

Kynurenic acid is a broad spectrum EAA antagonist. Putative GPR35 ligand. Kynurenic acid protects tissues in cardiac, cerebral, renal, and retinal ischemia models via activation of GPR35 and induction of ATP synthase dimerization in an ATPIF1-dependent and pertussis toxin (Cat. No. 3097) sensitive manner.

Sodium Salt also available.

Compound Libraries for Kynurenic acid

Kynurenic acid is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Kynurenic acid

M. Wt	189.17
Formula	C₁₀H₇NO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	492-27-3
PubChem ID	3845
InChi Key	HCZHHEIFKROPDY-UHFFFAOYSA-N
Smiles	OC(=O)C1=CC(O)=C2C=CC=CC2=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Kynurenic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	9.46	50
	1eq. NaOH	18.92	100

Preparing Stock Solutions for Kynurenic acid

The following data is based on the product molecular weight 189.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.29 mL	26.43 mL	52.86 mL
5 mM	1.06 mL	5.29 mL	10.57 mL
10 mM	0.53 mL	2.64 mL	5.29 mL
50 mM	0.11 mL	0.53 mL	1.06 mL

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Reconstitution Calculator

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References for Kynurenic acid

References are publications that support the biological activity of the product.

Wyant Mitochondrial remodeling and ischemic protection by G protein–coupled receptor 35 agonists. Science 2022 PMID: 35926043
Wang Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J.Biol.Chem. 2006 PMID: 16754668
Pittaluga The 'kynurenate test,' a biochemical assay for putative cognition enhancers. J.Pharmacol.Exp.Ther. 1997 PMID: 9336311
Stone and Burton NMDA receptors and ligands in the vertebrate CNS. Prog.Neurobiol. 1988 PMID: 2830636
Perkins and Stone An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res. 1982 PMID: 6215086