Kynurenic acid sodium salt

Name: Kynurenic acid sodium salt
Brand: Tocris Bioscience
SKU: 3694

Catalog # 3694 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

Sodium salt of kynurenic acid (Cat. No. 0223)

Key Product Details

Description:	Sodium salt of kynurenic acid (Cat. No. 0223)
Chemical Name:	4-Hydroxyquinoline-2-carboxylic acid sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	211.15

View Full Technical Details for Kynurenic acid sodium salt

Technical Data
Citations (2) / Reviews

Biological Activity for Kynurenic acid sodium salt

Kynurenic acid sodium salt is a sodium salt of kynurenic acid (Cat. No. 0223), a broad spectrum EAA antagonist.

Compound Libraries for Kynurenic acid sodium salt

Kynurenic acid sodium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Kynurenic acid sodium salt

M. Wt	211.15
Formula	C₁₀H₆NNaO₃
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	2439-02-3
PubChem ID	52974250
InChi Key	RCAZGXKUQDXSSK-UHFFFAOYSA-M
Smiles	[Na+].OC1=CC(=NC2=CC=CC=C12)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Kynurenic acid sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	21.11	100
	DMSO	10.56	50

Preparing Stock Solutions for Kynurenic acid sodium salt

The following data is based on the product molecular weight 211.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.74 mL	23.68 mL	47.36 mL
5 mM	0.95 mL	4.74 mL	9.47 mL
10 mM	0.47 mL	2.37 mL	4.74 mL
50 mM	0.09 mL	0.47 mL	0.95 mL

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Reconstitution Calculator

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References for Kynurenic acid sodium salt

References are publications that support the biological activity of the product.

Wang Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J.Biol.Chem. 2006 PMID: 16754668
Pittaluga The 'kynurenate test', a biochemical assay for putative cognition enhancers. J.Pharmacol.Exp.Ther. 1997 PMID: 9336311
Stone and Burton NMDA receptors and ligands in the vertebrate CNS. Progr.Neurobiol. 1988 PMID: 2830636
Perkins and Stone An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid. Brain Res. 1982 PMID: 6215086

Citations for Kynurenic acid sodium salt (2)

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Citations are publications that use Bio-Techne products. Selected citations for Kynurenic acid sodium salt include:

Stefano et al. (2022) Brainstem activation of GABAB receptors in the nucleus tractus solitarius increases gastric motility. Front Neurosci. 16:961042
PMID: 35983226
Ruilong et al. (2021) Long-Range GABAergic Inhibition Modulates Spatiotemporal Dynamics of the Output Neurons in the Olfactory Bulb. J Neurosci. 41:3610-3621
PMID: 33687961

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