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Pertussis Toxin

G Protein (Heterotrimeric) Inhibitors Small Molecule
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Description: Catalyzes ADP-ribosylation of Gi, Go and Gt

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Citations for Pertussis Toxin (20)

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  • Pertussis toxin impacts GABA-A receptor effects
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Pertussis toxin (PeTX) was used to compare effects of PKA and G-protein signalling on root mean square noise (RMS) produced by GABA-A receptors in electrophysiological recording. We found that after block of G-protein signalling with PeTX GABA-A receptor antagonists SR 95531 and Picrotoxin generate smaller impact on RMS noise than after block of PKA with PKI.
    Pertussis Toxin Serum 3097
  • Pertussis Toxin inhibits LPA induced COX-2 expression in osteosarcoma cells
    Name: Christopher Trummer
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    MG-63 cells were treated with LPA (10 µM) alone or in combination with C3 (20 µM), PTX (Pertussis Toxin, 400 ng/ml) or H2L 5765834 (20 µM) for 3 h to follow COX-2 expression using Western blot. Pertussis Toxin inhibited COX-2 expression induced by LPA.
    Pertussis Toxin Serum 3097
  • Fast delivery and great quality
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: CHO-KK1
    It was used to block gpcr response before hitting the cells with the ligand for receptor of interest

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