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8 results for "CRHR1 Small Molecules and Peptides" in Products

CRHR1: Small Molecules and Peptides

CRHR1, also known as CHR-R1 and Corticotropin Releasing Factor Receptor 1, CRF 1, is a member of the Class B G protein-coupled receptor family that mediates the action of hypothalamic and peripheral CRH. It is the key regulator of the stress response in the hypothalamic-pituitary adrenal axis and an important functional mediator of the endocrine, cardiovascular, gastrointestinal, and immune systems. The other major endogenous ligand for CRHR1 is Urocortin 1.

Potent and selective CRF1 antagonist; anxiolytic

Chemical Name: 8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine
Purity: ≥98% (HPLC)
Potent and selective CRF1 antagonist; anxiolytic

Selective, non-peptide CRF1 antagonist

Chemical Name: N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
Purity: ≥98% (HPLC)
Selective, non-peptide CRF1 antagonist

Potent and selective CRF1 antagonist; binds at an allosteric site

Chemical Name: N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride
Purity: ≥98% (HPLC)
Potent and selective CRF1 antagonist; binds at an allosteric site

High affinity CRF1 antagonist; orally bioavailable

Chemical Name: 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine hydrochloride
Purity: ≥98% (HPLC)
High affinity CRF1 antagonist; orally bioavailable

Potent and selective CRF1 antagonist

Chemical Name: (7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride
Purity: ≥98% (HPLC)
Potent and selective CRF1 antagonist

CRF1 antagonist

Chemical Name: N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
Purity: ≥98% (HPLC)
CRF1 antagonist

Selective non-peptide CRF1 antagonist

Chemical Name: 5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride
Purity: ≥98% (HPLC)
Selective non-peptide CRF1 antagonist

CRF1 agonist

Alternate Names: cyclo(31-34)[D-Phe12,Nle21,38,Glu31,Lys34]Ac-hCRF (4-41)
Purity: ≥95% (HPLC)
CRF1 agonist
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