NBI 35965 hydrochloride

Name: NBI 35965 hydrochloride
Brand: Tocris Bioscience
SKU: 3100
Price: 273 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 3100

Citations (2)

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Key Product Details

Description:	Potent and selective CRF₁ antagonist
Chemical Name:	(7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	437.79

View Full Technical Details for NBI 35965 hydrochloride

Biological Activity for NBI 35965 hydrochloride

NBI 35965 hydrochloride is a potent and selective corticotropin-releasing factor receptor 1 (CRF₁) antagonist (K_i values are 4 and > 10000 nM at CRF₁ and CRF₂ respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC₅₀ values are 7.1 and 6.9 respectively) and attenuates CRF and ACTH production in vivo. Orally active and brain penetrant with anxiolytic activity.

Compound Libraries for NBI 35965 hydrochloride

NBI 35965 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NBI 35965 hydrochloride

M. Wt	437.79
Formula	C₂₁H₂₂Cl₂N₄.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1782228-59-4
PubChem ID	71433630
InChi Key	LNYUWBPFYXPUIO-RSAXXLAASA-N
Smiles	CC[C@@H]3N(CC5CC5)C1=C2C(C(C4=CC=C(Cl)C=C4Cl)=NN2C3)=NC(C)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NBI 35965 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	43.78	100
	DMSO	43.78	100

Preparing Stock Solutions for NBI 35965 hydrochloride

The following data is based on the product molecular weight 437.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.42 mL	22.84 mL
5 mM	0.46 mL	2.28 mL	4.57 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for NBI 35965 hydrochloride

References are publications that support the biological activity of the product.

Gross Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists. J.Med.Chem. 2005 PMID: 16134945
Million A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats. Brain Res. 2003 PMID: 12957366
Hoare Mechanism of corticotropin-releasing factor type I receptor regulation by non-peptide antagonists. Mol.Pharmacol. 2003 PMID: 12606786

Citations for NBI 35965 hydrochloride (2)

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Citations are publications that use Bio-Techne products. Selected citations for NBI 35965 hydrochloride include:

Martinon and Dabrowska (2018) Corticotropin-Releasing Factor Receptors Modulate OXT Release in the Dorsolateral Bed Nucleus of the Stria Terminalis (BNST) in Male Rats. Front Neurosci. 12:183
PMID: 29618970
Abdelhamid et al. (2013) Forced swim-induced musculoskeletal hyperalgesia is mediated by CRF2 receptors but not by TRPV1 receptors. Neuropharmacology. 72:29
PMID: 23624287

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Product Documents for NBI 35965 hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.