NBI 27914 hydrochloride

Name: NBI 27914 hydrochloride
Brand: Tocris Bioscience
SKU: 1591

Tocris Bioscience, part of Bio-Techne | Catalog # 1591

Citations (6)

COA / SDS

Selective non-peptide CRF1 antagonist

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective non-peptide CRF1 antagonist

View all CRF1 Receptor Antagonists »

Product Description

NBI 27914 hydrochloride is a selective, non-peptide corticotropin-releasing factor₁ (CRF₁) receptor antagonist (K_i = 1.7 nM); has no activity at CRF₂ receptors. Blocks behavioral seizures in vivo.

Product Specifications

Molecular Weight

470.66

Formula

C₁₈H₂₀Cl₄N₄.HCl

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

5-Chloro-N-(cyclopropylmethyl)-2-methyl-N-propyl-N'-(2,4,6-trichlorophenyl)-4,6-pyrimidinediamine hydrochloride

CAS Number

1215766-76-9

PubChem ID

45073446

InChI Key

CPMGENCTAWBLNW-UHFFFAOYSA-N

SMILES

Cl.CCCN(CC1CC1)C1=C(Cl)C(NC2=C(Cl)C=C(Cl)C=C2Cl)=NC(C)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.42	100
	Ethanol	43.42	100

Preparing Stock Solutions for NBI 27914 hydrochloride

The following data is based on the product molecular weight 470.66

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.62 mL	21.25 mL
5 mM	0.42 mL	2.12 mL	4.25 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Chen Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor₁ receptor antagonists. J.Med.Chem. 1996 PMID: 8893829
McCarthy Recent advances with the CRF₁ receptor: design of small molecule inhibitors, receptor subtypes and clinical indications. Curr.Pharm.Des. 1999 PMID: 10213797
Baram The CRF₁ receptor mediates the excitatory actions of cortico. releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res. 1997 PMID: 9372207