CP 376395 hydrochloride

Name: CP 376395 hydrochloride
Brand: Tocris Bioscience
SKU: 3212

Tocris Bioscience a Bio-Techne Brand

Catalog # 3212

Citations (3)

COA / SDS

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Key Product Details

Description:	Potent and selective CRF₁ antagonist; binds at an allosteric site
Chemical Name:	N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	362.94

View Full Technical Details for CP 376395 hydrochloride

Biological Activity for CP 376395 hydrochloride

CP 376395 hydrochloride is a potent and selective CRF₁ receptor antagonist (K_i values are 12 and >10000 nM for CRF₁ and CRF₂ receptors respectively). Binds at an allosteric site. Attenuates CRF-induced activation of the HPA axis in vivo following i.v. administration. Orally active.

Compound Libraries for CP 376395 hydrochloride

CP 376395 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 376395 hydrochloride

M. Wt	362.94
Formula	C₂₁H₃₀N₂O.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1013933-37-3
PubChem ID	24806455
InChi Key	UDIOZDHQQNYISB-UHFFFAOYSA-N
Smiles	CC1=CC(NC(CC)CC)=C(C)C(OC2=C(C)C=C(C)C=C2C)=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CP 376395 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	18.15	50
	DMSO	36.29	100

Preparing Stock Solutions for CP 376395 hydrochloride

The following data is based on the product molecular weight 362.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.78 mL	27.55 mL
5 mM	0.55 mL	2.76 mL	5.51 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for CP 376395 hydrochloride

References are publications that support the biological activity of the product.

Lu Small molecule allosteric modulators of G-protein-coupled receptors: drug-target interactions. J.Med.Chem. 2019 PMID: 29457894
Hollenstein Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature 2013 PMID: 23863939
Chen 2-Aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J.Med.Chem. 2008 PMID: 18288792

Citations for CP 376395 hydrochloride (3)

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Citations are publications that use Bio-Techne products. Selected citations for CP 376395 hydrochloride include:

Kean et al. (2015) Conformational thermostabilisation of cortico. releasing factor receptor 1. Mol Pain. 5:11954
PMID: 26159865
Boyson et al. (2014) Social stress and CRF-DA interactions in the VTA: role in long-term escalation of cocaine self-administration. J Neurosci. 34:6659
PMID: 24806691
Tran et al. (2014) Importance of CRF receptor-mediated mechanisms of the bed nucleus of the stria terminalis in the processing of anxiety and pain. Neuropsychopharmacology. 39:2633
PMID: 24853772

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Product Documents for CP 376395 hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.