CP 376395 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3212
Potent and selective CRF1 antagonist; binds at an allosteric site
Key Product Details
Description
Potent and selective CRF1 antagonist; binds at an allosteric site
Product Description
CP 376395 hydrochloride is a potent and selective CRF1 receptor antagonist (Ki values are 12 and >10000 nM for CRF1 and CRF2 receptors respectively). Binds at an allosteric site. Attenuates CRF-induced activation of the HPA axis in vivo following i.v. administration. Orally active.Product Specifications
Molecular Weight
362.94
Formula
C21H30N2O.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-(1-Ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-4-pyridinamine hydrochloride
CAS Number
1013933-37-3
PubChem ID
24806455
InChI Key
UDIOZDHQQNYISB-UHFFFAOYSA-N
SMILES
CC1=CC(NC(CC)CC)=C(C)C(OC2=C(C)C=C(C)C=C2C)=N1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 18.15 | 50 | |
| DMSO | 36.29 | 100 |
Preparing Stock Solutions
for CP 376395 hydrochloride
The following data is based on the product molecular weight 362.94
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.76 mL | 13.78 mL | 27.55 mL |
| 5 mM | 0.55 mL | 2.76 mL | 5.51 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.76 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hollenstein Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature 2013 PMID: 23863939
- Lu Small molecule allosteric modulators of G-protein-coupled receptors: drug-target interactions. J.Med.Chem. 2019 PMID: 29457894
- Chen 2-Aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J.Med.Chem. 2008 PMID: 18288792
Product Specific Notices for CP 376395 hydrochloride
For research use only
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