CP 154526
Tocris Bioscience, part of Bio-Techne | Catalog # 2779
Selective, non-peptide CRF1 antagonist
Key Product Details
Description
Selective, non-peptide CRF1 antagonist
Product Description
CP 154526 is a selective, non-peptide CRF1 receptor antagonist (Ki values are 2.7 and > 10000 nM for CRF1 and CRF2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (Ki = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
400.99
Formula
C23H32N4.HCl
Storage
Desiccate at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
CAS Number
257639-98-8
PubChem ID
11475094
InChI Key
ZWDLBNCJWNENFF-UHFFFAOYSA-N
SMILES
CC1=CN(C3=C(C)C=C(C)C=C3C)C2=C1C(N(CC)CCCC)=NC(C)=N2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.05 | 50 | |
| Ethanol | 20.05 | 50 |
Preparing Stock Solutions
for CP 154526
The following data is based on the product molecular weight 400.99
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.99 mL | 24.94 mL | 49.88 mL |
| 2.5 mM | 1.00 mL | 4.99 mL | 9.98 mL |
| 5 mM | 0.50 mL | 2.49 mL | 4.99 mL |
| 25 mM | 0.10 mL | 0.50 mL | 1.00 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hodgson Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression. Pharmacol.Biochem.Behav. 2007 PMID: 17291571
- Schulz CP-154,526: a potent and selective nonpeptide antagonist of cortico. releasing factor receptors. Proc.Natl.Acad.Sci.USA 1996 PMID: 8816826
- Lundkist A non peptidic cortico. releasing factor receptor antagonist attenuates fever and exhibits anxiolytic activity. Eur.J.Pharmacol. 1996 PMID: 8874139
Product Specific Notices for CP 154526
For research use only
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