Antalarmin hydrochloride

Name: Antalarmin hydrochloride
Brand: Tocris Bioscience
SKU: 2778

Tocris Bioscience, part of Bio-Techne | Catalog # 2778

Citations (18)

COA / SDS

CRF1 antagonist

Key Product Details

Description:	CRF₁ antagonist
Chemical Name:	N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	415.01

View Full Technical Details for Antalarmin hydrochloride

Technical Data
Citations

Biological Activity for Antalarmin hydrochloride

Antalarmin hydrochloride is a non-peptide corticotropin-releasing hormone receptor 1 (CRF₁) antagonist (K_i = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.

Compound Libraries for Antalarmin hydrochloride

Antalarmin hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Antalarmin hydrochloride

M. Wt	415.01
Formula	C₂₄H₃₄N₄.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	220953-69-5
PubChem ID	16078945
InChi Key	CGDGXEDXEXACKQ-UHFFFAOYSA-N
Smiles	CC1=C(C)N(C3=C(C)C=C(C)C=C3C)C2=C1C(N(CC)CCCC)=NC(C)=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Antalarmin hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.5	100
	ethanol	41.5	100

Preparing Stock Solutions for Antalarmin hydrochloride

The following data is based on the product molecular weight 415.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.05 mL	24.10 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
10 mM	0.24 mL	1.20 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for Antalarmin hydrochloride

References are publications that support the biological activity of the product.

Zorrilla Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Res. 2002 PMID: 12376179
Specio CRF1 receptor antagonists attenuate escalated cocaine self-administration in rats. Psychopharmacol. 2008 PMID: 17965976
Webster In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. Endocrinology 1996 PMID: 8940412