Stressin I

Name: Stressin I
Brand: Tocris Bioscience
SKU: 1608
Rating: 5 (0 reviews)

Catalog # 1608 | Tocris Bioscience a Bio-Techne Brand

Citations (2)

COA / SDS

CRF1 agonist

Key Product Details

Description:	CRF₁ agonist
Alternative Names:	cyclo(31-34)[D-Phe¹²,Nle^21,38,Glu³¹, Lys³⁴]Ac-hCRF (4-41)
Purity:	≥95% (HPLC)
Molecular Weight:	4472.24

View Full Technical Details for Stressin I

Technical Data
Citations (2) / Reviews

Biological Activity for Stressin I

Stressin I is a potent and selective corticotropin releasing factor receptor-1 (CRF₁) agonist (K_i values are 1.5 and 224 nM for CRF₁ and CRF₂ receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.

Licensing Information

Sold with the permission of the SALK Institute

Technical Data for Stressin I

M. Wt	4472.24
Formula	C₂₀₃H₃₃₇N₅₇O₅₆
Single Letter Sequence	PPISLDLTFHLLREVLEXARAEQLAQQEHSKRKLXEII (Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
PubChem ID	90479815
InChi Key	HZKFMBAUDWRPRY-WNBAZHKDSA-N
Smiles	CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(C)=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Stressin I

Solubility

Soluble to 1mg/ml in water

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References for Stressin I

References are publications that support the biological activity of the product.

Bruchas CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. PLoS One. 2009 PMID: 20052275
Rivier Stressin₁-A, a potent cortico. releasing factor receptor 1 (CRF₁)-selective peptide agonist. J.Med.Chem. 2007 PMID: 17335188
Rivier Receptor-selective cortico. releasing factor analogs. Endocrin.Soc.Abstr.

Citations for Stressin I (2)

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Citations are publications that use Bio-Techne products. Selected citations for Stressin I include:

Silberman and Winder (2013) Corticotropin releasing factor and catecholamines enhance glutamatergic neurotransmission in the lateral subdivision of the central amygdala. Neuropharmacology. 70:316
PMID: 23470280
Land et al. (2008) The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci. 28:407
PMID: 18184783

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Customer Reviews for Stressin I (1)

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Stressin 1 modulation of GABA transmission

Name: Anonymous

Assay Type: In Vitro

Exogenous application of various concentrations onto acute brain slices was used to examine CRF1 receptor modulation of GABA transmission in the central amygdala.

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