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B7-H3 Products

B7-H3 is an immunoglobulin superfamily protein that is expressed by osteoblasts, fibroblasts, ciliated respiratory epithelial cells, anterior pituitary progenitor cells, first trimester extravillous trophoblasts, and multiple tumor cells. It is induced on activated dendritic cells (DC), skeletal muscle myocytes, and monocytes. B7-H3 can both stimulate and inhibit immune cell activation. As a co-stimulator, B7-H3 augments macrophage activation and promotes proliferation and cytokine secretion by CD4+ and CD8+ T cells. As a co-inhibitor, tumor cell B7-H3 blocks the cytolytic activity of NK cells, limits cytokine production by activated T cells, and imparts an immunosuppressive phenotype to dendritic cells. B7-H3 can interact with TREML2/TLT-2 to enhance T cell activation including the CD8+ T cell-mediated lysis of tumor cells.

140 results for "B7-H3" in Products

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B7-H3 Products

B7-H3 is an immunoglobulin superfamily protein that is expressed by osteoblasts, fibroblasts, ciliated respiratory epithelial cells, anterior pituitary progenitor cells, first trimester extravillous trophoblasts, and multiple tumor cells. It is induced on activated dendritic cells (DC), skeletal muscle myocytes, and monocytes. B7-H3 can both stimulate and inhibit immune cell activation. As a co-stimulator, B7-H3 augments macrophage activation and promotes proliferation and cytokine secretion by CD4+ and CD8+ T cells. As a co-inhibitor, tumor cell B7-H3 blocks the cytolytic activity of NK cells, limits cytokine production by activated T cells, and imparts an immunosuppressive phenotype to dendritic cells. B7-H3 can interact with TREML2/TLT-2 to enhance T cell activation including the CD8+ T cell-mediated lysis of tumor cells.

140 results for "B7-H3" in Products

WB, Simple Western, Flow, IHC, CyTOF-ready, KO
BA
WB, Flow, CyTOF-ready, KO
BA, BA

Biotinylated long-form B7-H3 (4Ig)/B7-H3b

BA
BA, BA

Biotinylated

ICC

Recombinant Monoclonal Antibody.

WB

Recombinant Monoclonal Antibody.

Flow, ICC/IF, IHC, IP, WB

Recombinant Monoclonal

WB
WB, IHC
ICC/IF, IHC, KO, WB
Flow
BA
BA, BA, Bind
Catalog #: FAB1027R
Flow
Flow
Results Per Page
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