B7-H3 Products
B7-H3 is an immunoglobulin superfamily protein that is expressed by osteoblasts, fibroblasts, ciliated respiratory epithelial cells, anterior pituitary progenitor cells, first trimester extravillous trophoblasts, and multiple tumor cells. It is induced on activated dendritic cells (DC), skeletal muscle myocytes, and monocytes. B7-H3 can both stimulate and inhibit immune cell activation.
As a co-stimulator, B7-H3 augments macrophage activation and promotes proliferation and cytokine secretion by CD4+ and CD8+ T cells. As a co-inhibitor, tumor cell B7-H3 blocks the cytolytic activity of NK cells, limits cytokine production by activated T cells, and imparts an immunosuppressive phenotype to dendritic cells. B7-H3 can interact with TREML2/TLT-2 to enhance T cell activation including the CD8+ T cell-mediated lysis of tumor cells.
Products:
307 results for "B7-H3" in Products
307 results for "B7-H3" in Products
B7-H3 Products
B7-H3 is an immunoglobulin superfamily protein that is expressed by osteoblasts, fibroblasts, ciliated respiratory epithelial cells, anterior pituitary progenitor cells, first trimester extravillous trophoblasts, and multiple tumor cells. It is induced on activated dendritic cells (DC), skeletal muscle myocytes, and monocytes. B7-H3 can both stimulate and inhibit immune cell activation.
As a co-stimulator, B7-H3 augments macrophage activation and promotes proliferation and cytokine secretion by CD4+ and CD8+ T cells. As a co-inhibitor, tumor cell B7-H3 blocks the cytolytic activity of NK cells, limits cytokine production by activated T cells, and imparts an immunosuppressive phenotype to dendritic cells. B7-H3 can interact with TREML2/TLT-2 to enhance T cell activation including the CD8+ T cell-mediated lysis of tumor cells.
Products:
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, Flow, IHC, CyTOF-ready, +1 More |
| Source: | NS0 |
| Accession #: | Q5ZPR3 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | NP_079516 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | NP_079516 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | WB, Flow, CyTOF-ready, KO |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #1090036 |
| Applications: | WB, Simple Western, IHC, mIF |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Source: | NS0 |
| Accession #: | Q8VE98.1 |
| Applications: | BA |
| Sensitivity: | 0.274 ng/mL |
| Applications: | ELISA |
| Assay Range: | 0.781 - 50 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, KO |
![Knockout Validated: B7-H3/CD276 Antibody [NBP1-88965]](https://resources.bio-techne.com/images/products/B7-H3-CD276-Antibody-Knockout-Validated-NBP1-88965-img0014.jpg "Western Blot: B7-H3/CD276 Antibody [NBP1-88965]")
Biotinylated long-form B7-H3 (4Ig)/B7-H3b
| Source: | HEK293 |
| Accession #: | Q5ZPR3-1 |
| Applications: | BA, BA |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
| Source: | NS0 |
| Accession #: | NP_079516.1 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | Flow |
Recombinant Monoclonal
| Reactivity: | Human, Mouse |
| Details: | Rabbit Monoclonal Clone #BLR025F |
| Applications: | IHC, WB, ICC/IF, Flow, IP |
![Western Blot: B7-H3/CD276 Antibody (BLR025F) [NBP3-14669]](https://resources.bio-techne.com/images/products/B7-H3-CD276-Antibody-Western-Blot-NBP3-14669-img0002.jpg "Western Blot: B7-H3/CD276 Antibody (BLR025F) [NBP3-14669]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, KO |
![Knockout Validated: B7-H3/CD276 Antibody [NBP1-88966]](https://resources.bio-techne.com/images/products/B7-H3-CD276-Antibody-Knockout-Validated-NBP1-88966-img0016.jpg "Western Blot: B7-H3/CD276 Antibody [NBP1-88966]")
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
Biotinylated
| Source: | CHO |
| Accession #: | NP_079516.1 |
| Applications: | BA, BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | Flow |
| Assay Range: | 0.781 - 50 ng/mL |
| Applications: | ELISA |
| Source: | NS0 |
| Accession #: | NP_079516.1 |
| Applications: | BA |
Recombinant Monoclonal Antibody.
| Reactivity: | Mouse |
| Details: | Rabbit IgG Monoclonal Clone #2741E |
| Applications: | Flow, ICC |
| Source: | NS0 |
| Accession #: | Q7TPB4.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q8VE98.1 |
| Applications: | BA |
