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B7-H3 Products
B7-H3 is an immunoglobulin superfamily protein that is expressed by osteoblasts, fibroblasts, ciliated respiratory epithelial cells, anterior pituitary progenitor cells, first trimester extravillous trophoblasts, and multiple tumor cells. It is induced on activated dendritic cells (DC), skeletal muscle myocytes, and monocytes. B7-H3 can both stimulate and inhibit immune cell activation. As a co-stimulator, B7-H3 augments macrophage activation and promotes proliferation and cytokine secretion by CD4+ and CD8+ T cells. As a co-inhibitor, tumor cell B7-H3 blocks the cytolytic activity of NK cells, limits cytokine production by activated T cells, and imparts an immunosuppressive phenotype to dendritic cells. B7-H3 can interact with TREML2/TLT-2 to enhance T cell activation including the CD8+ T cell-mediated lysis of tumor cells.
38 results for "B7-H3" in Products
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B7-H3 Products
B7-H3 is an immunoglobulin superfamily protein that is expressed by osteoblasts, fibroblasts, ciliated respiratory epithelial cells, anterior pituitary progenitor cells, first trimester extravillous trophoblasts, and multiple tumor cells. It is induced on activated dendritic cells (DC), skeletal muscle myocytes, and monocytes. B7-H3 can both stimulate and inhibit immune cell activation. As a co-stimulator, B7-H3 augments macrophage activation and promotes proliferation and cytokine secretion by CD4+ and CD8+ T cells. As a co-inhibitor, tumor cell B7-H3 blocks the cytolytic activity of NK cells, limits cytokine production by activated T cells, and imparts an immunosuppressive phenotype to dendritic cells. B7-H3 can interact with TREML2/TLT-2 to enhance T cell activation including the CD8+ T cell-mediated lysis of tumor cells.
38 results for "B7-H3" in Products
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Catalog #:
1949-B3
BA
| Source : | NS0 |
| Accession # : | NP_079516 |
| Applications : | Bioactivity |
WB, Simple Western, Flow, IHC, CyTOF-ready, KO
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | CyTOF-ready, Flow Cytometry, Immunohistochemistry, Knockout Validated, Simple Western, Western Blot |
BA
| Source : | NS0 |
| Accession # : | NP_079516 |
| Applications : | Bioactivity |
Catalog #:
AVI2318
BA
Biotinylated long-form B7-H3 (4Ig)/B7-H3b
| Source : | HEK293 |
| Accession # : | Q5ZPR3-1 |
| Applications : | Bioactivity |
BA
| Source : | NS0 |
| Accession # : | Q5ZPR3 |
| Applications : | Bioactivity |
WB, Flow, CyTOF-ready, KO
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #185504 |
| Applications : | CyTOF-ready, Flow Cytometry, Knockout Validated, Western Blot |
Catalog #:
AVI10381
BA, Bind
| Source : | CHO |
| Accession # : | Q5ZPR3.1 |
| Applications : | Binding Activity, Bioactivity |
WB, Neut
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Block/Neutralize, Western Blot |
Catalog #:
9426-B3
BA
| Source : | HEK293 |
| Accession # : | XP_015308534 |
| Applications : | Bioactivity |
Catalog #:
10610-B3
BA
| Source : | NS0 |
| Accession # : | Q7TPB4.1 |
| Applications : | Bioactivity |
Catalog #:
1397-B3
BA
| Source : | NS0 |
| Accession # : | Q8VE98.1 |
| Applications : | Bioactivity |
ELISA
| Sensitivity : | 0.274 ng/mL |
| Assay Range : | 0.781 - 50 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
| Applications : | ELISA |
Catalog #:
AVI1027
BA
Biotinylated
| Source : | CHO |
| Accession # : | NP_079516.1 |
| Applications : | Bioactivity |
Catalog #:
BT1027
BA
| Source : | NS0 |
| Accession # : | NP_079516 |
| Applications : | Bioactivity |
Catalog #:
BAF1027
WB, IHC
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunohistochemistry, Western Blot |
Catalog #:
BAF1397
WB
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Western Blot |
Catalog #:
FAB1027R
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #185504 |
| Applications : | Flow Cytometry |
Catalog #:
FAB1027G
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #185504 |
| Applications : | Flow Cytometry |
Catalog #:
FAB1027A
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #185504 |
| Applications : | Flow Cytometry |
Catalog #:
FAB1027U
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #185504 |
| Applications : | Flow Cytometry |
Catalog #:
FAB1027S
Flow
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #185504 |
| Applications : | Flow Cytometry |
Catalog #:
DY1949-05
ELISA
| Assay Range : | 0.781 - 50 ng/mL |
| Applications : | ELISA |
Catalog #:
MAB1397
WB
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #2741D |
| Applications : | Western Blot |
Catalog #:
10472-B3
BA
| Source : | HEK293 |
| Applications : | Bioactivity |
