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Akt (Protein Kinase B) Inhibitors Products

Akt1, Akt2, and Akt3 make up a family of serine/threonine kinases, often activated downstream of growth factor receptors and PI 3-Kinase. Each Akt family member contains an N-terminal pleckstrin homology (PH) domain, a central kinase domain, and a C-terminal regulatory domain. They have putative roles in cell proliferation and survival, and Akt perturbations are thought to play an important role in tumorigenesis.

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10 results for "Akt (Protein Kinase B) Inhibitors" in Products

10 results for "Akt (Protein Kinase B) Inhibitors" in Products

Akt (Protein Kinase B) Inhibitors Products

Akt1, Akt2, and Akt3 make up a family of serine/threonine kinases, often activated downstream of growth factor receptors and PI 3-Kinase. Each Akt family member contains an N-terminal pleckstrin homology (PH) domain, a central kinase domain, and a C-terminal regulatory domain. They have putative roles in cell proliferation and survival, and Akt perturbations are thought to play an important role in tumorigenesis.

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Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates

Chemical Name: 6-(2-Benzothiazolyl)-1-ethyl-2-[(1E)-2-(methylphenylamino)ethenyl]-3-phenyl-1H-benzimidazolium iodide
Purity: ≥98% (HPLC)
Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates

Potent and selective allosteric Akt1, Akt2 and Akt3 inhibitor

Chemical Name: 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride
Purity: ≥98% (HPLC)
Potent and selective allosteric Akt1, Akt2 and Akt3 inhibitor

Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral

Alternate Names: Triciribine,NSC 154020,TCN
Chemical Name: 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
Purity: ≥98% (HPLC)
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral

PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

Chemical Name: 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one
Purity: ≥98% (HPLC)
PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

Selective Akt/PKB inhibitor

Alternate Names: Akt Inhibitor X
Chemical Name: 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride
Purity: ≥98% (HPLC)
Selective Akt/PKB inhibitor

Akt kinase inhibitor. Antitumor

Chemical Name: 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
Purity: ≥98% (HPLC)
Akt kinase inhibitor. Antitumor

Potent pan-Akt and PKA inhibitor

Chemical Name: 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine hydrochloride
Purity: ≥98% (HPLC)
Potent pan-Akt and PKA inhibitor

Potent pan-AKT inhibitor

Alternate Names: Capivasertib
Chemical Name: 4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide
Purity: ≥98% (HPLC)
Potent pan-AKT inhibitor

PKB/Akt inhibitor; also modulates Kv2.1 current

Alternate Names: KRX-0401
Chemical Name: Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate
Purity: ≥98% (HPLC)
PKB/Akt inhibitor; also modulates Kv2.1 current

Potent and selective dual Akt1 and 2 inhibitor

Alternate Names: Akt Inhibitor VIII
Chemical Name: 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one
Purity: ≥98% (HPLC)
Potent and selective dual Akt1 and 2 inhibitor
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