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Akt (Protein Kinase B) Inhibitors Small Molecule
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Description: Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
Alternative Names: Triciribine, NSC 154020, TCN
Chemical Name: 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
Purity: ≥99% (HPLC)
Molecular Weight: 320.31

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  • Attenuation by co-treatment of either PI3K inhibitor LY94002 or Akt inhibitor API-2
    Name: Zhenmin Lei
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Ovarian theca cells
    The isolated mouse ovarian theca cells were maintained in 12-well plates withRPMI-1640 medium. For determination of Lhcgr expression, thecells were rinsed three times with PBS the day before incubation with vehicle(DMSO), 740YP (50 mg/ml), 740YP + API-2 (7.5 mM), LH (50 ng/mL),or LH + API-2 for 24 h. For determination of Akt phosphorylation,PBS rinsed cells were incubated with vehicle (DMSO), or API-2 (7.5 mM) in serum-free RPMI-medium for 1 h before the addition of LH (50 ng/mL) for 30 min.
    API-2 Serum 2151

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