Key Product Details
Description: | Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral |
Alternative Names: | Triciribine, NSC 154020, TCN |
Chemical Name: | 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine |
Purity: | ≥99% (HPLC) |
Molecular Weight: | 320.31 |
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Citations for API-2 (17)
Citations are publications that use Bio-Techne products. Selected citations for API-2 include:
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Yuan et al.
(2019)
IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth development.
Cell Death Dis.
10:63
PMID: 30683845 -
Suarez et al.
(2017)
The AKT inhibitor triciribine in combination with PTX has order-specific efficacy against Zfp217-induced breast cancer chemoresistance.
Oncotarget.
8:108534
PMID: 29312549 -
Ali et al.
(2017)
Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1.
BMC Cancer.
17:803
PMID: 29187162 -
Arqués et al.
(2016)
Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer.
Clin Cancer Res.
22:644
PMID: 26224873 -
Rosenberg et al.
(2015)
Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression.
Biol Open.
8:42614
PMID: 25749171 -
Kana et al.
(2015)
PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System.
Tissue Eng Part A.
21:2379
PMID: 26120935 -
Kuo et al.
(2014)
Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by Ins.
J Lipid Res.
55:919
PMID: 24565756 -
Shravah et al.
(2014)
PropF. mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT.
Am J Physiol Renal Physiol.
3:e29554
PMID: 25105067 -
Robertson et al.
(2013)
Sea urchin akt activity is Runx-dependent and required for post-cleavage stage cell division.
Blood.
2:472
PMID: 23789095 -
Woo et al.
(2012)
Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking.
J Biol Chem.
287:3963
PMID: 22117079 -
Duan et al.
(2011)
mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR.
JAKSTAT.
44:317
PMID: 22017877 -
Barber and Sentman
(2011)
NKG2D receptor regulates human effector T-cell cytokine production.
Mol Cell.
117:6571
PMID: 21518928 -
Sunters et al.
(2010)
Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i
J Biol Chem.
285:8743
PMID: 20042609 -
Jackson et al.
(2010)
Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.
PLoS One.
5:e11962
PMID: 20694145 -
Liu et al.
(2010)
FRP inhibits ox-LDL-induced endothelial cell apoptosis through an Akt-NF-{kappa}B-Bcl-2 pathway and inhibits endothelial cell apoptosis in an apoE-knockout mouse model.
Am J Physiol Endocrinol Metab.
299:E351
PMID: 20530739 -
Roselli et al.
(2009)
Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
PLoS One.
4:e6011
PMID: 19547699 -
Madhunapantula et al.
(2007)
PRAS40 deregulates apoptosis in malignant melanoma.
Cancer Res.
67:3626
PMID: 17440074
There are no citations that match your criteria.
Customer Reviews for API-2 (1)
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Species: MouseAssay Type: In VitroCell Line/Tissue: Ovarian theca cellsThe isolated mouse ovarian theca cells were maintained in 12-well plates withRPMI-1640 medium. For determination of Lhcgr expression, thecells were rinsed three times with PBS the day before incubation with vehicle(DMSO), 740YP (50 mg/ml), 740YP + API-2 (7.5 mM), LH (50 ng/mL),or LH + API-2 for 24 h. For determination of Akt phosphorylation,PBS rinsed cells were incubated with vehicle (DMSO), or API-2 (7.5 mM) in serum-free RPMI-medium for 1 h before the addition of LH (50 ng/mL) for 30 min.
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