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10-DEBC hydrochloride

Bio-Techne includes Tocris Bioscience | Catalog # 2558

Selective Akt/PKB inhibitor
Selective Akt/PKB inhibitor

Key Product Details

Description: Selective Akt/PKB inhibitor
Alternative Names: Akt Inhibitor X
Chemical Name: 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride
Purity: ≥99% (HPLC)
Molecular Weight: 381.34

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  • Inhibition of Akt/PKB in BV2 microglia cells
    Name: Joanna Plastira
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: BV2 microglia cells
    As part of our current study, we investigated the role of AKT pathway on the LPA induced inflammatory phenotype in microglia (downstream signaling). BV2 cells were incubated for different time points with LPA (1µM) in the presence or absence of AKT X (5µM). AKT inhibition totally decreased the expression of 2 pro-inflammatory transcription factors (pSTAT1 and pp65). The inhibitor was diluted in water.
    10-DEBC hydrochloride Serum 2558

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Product Documents for 10-DEBC hydrochloride

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