GSK 690693

Name: GSK 690693
Brand: Tocris Bioscience
SKU: 4144
Rating: 5 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4144

Citations (3)

(1)

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Key Product Details

Description:	Akt kinase inhibitor. Antitumor
Chemical Name:	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
Purity:	≥98% (HPLC)
Molecular Weight:	425.48

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Biological Activity for GSK 690693

GSK 690693 is an ATP-competitive pan-Akt kinase inhibitor (IC₅₀ values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC₅₀

Licensing Information

Sold for research purposes only under agreement from GlaxoSmithKline

Compound Libraries for GSK 690693

GSK 690693 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK 690693

M. Wt	425.48
Formula	C₂₁H₂₇N₇O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	937174-76-0
PubChem ID	90488916
InChi Key	WONPMIMNXYCXKK-AWEZNQCLSA-N
Smiles	NC1=NON=C1C(N3CC)=NC2=C3C(CO[C@@H]4CNCCC4)=CN=C2C#CC(C)(C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 690693

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.27	50

Preparing Stock Solutions for GSK 690693

The following data is based on the product molecular weight 425.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.70 mL	23.50 mL	47.01 mL
2.5 mM	0.94 mL	4.70 mL	9.40 mL
5 mM	0.47 mL	2.35 mL	4.70 mL
25 mM	0.09 mL	0.47 mL	0.94 mL

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References for GSK 690693

References are publications that support the biological activity of the product.

Heerding Identification of 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{(3S)-3-piperidinylmethoxyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J.Med.Chem. 2008 PMID: 18800763
Rhodes Characterization of an Akt inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res. 2008 PMID: 18381444

Citations for GSK 690693 (3)

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Citations are publications that use Bio-Techne products. Selected citations for GSK 690693 include:

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. J Mol Neurosci. 10:e0143319
PMID: 26619345
Sokołowska et al. (2014) Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. Stem Cell Reports. 52:48
PMID: 24243084
Khuituan et al. (2012) Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D₃-enhanced duodenal calcium transport in male mice. Am J Physiol Endocrinol Metab. 302:E903
PMID: 22275752

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Customer Reviews for GSK 690693 (1)

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Effects on Akt kinase activation in cancer

Name: MARINA KOUTSIOUMPA

Species: Human

Assay Type: In Vitro

GSK 690693 inhibitor was used in studies exploring the role of drug-induced activation of Akt kinase in pancreatic cancer cells. Results were consistent.

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Product Documents for GSK 690693

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.