GSK 690693

Name: GSK 690693
Brand: Tocris Bioscience
SKU: 4144
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4144

(1)

Citations (20)

COA / SDS

Akt kinase inhibitor. Antitumor

Key Product Details

Description:	Akt kinase inhibitor. Antitumor
Chemical Name:	4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
Purity:	≥98% (HPLC)
Molecular Weight:	425.48

View Full Technical Details for GSK 690693

Technical Data
Citations / Reviews (1)

Biological Activity for GSK 690693

GSK 690693 is an ATP-competitive pan-Akt kinase inhibitor (IC₅₀ values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC₅₀ < 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.

Licensing Information

Sold for research purposes only under agreement from GlaxoSmithKline

Compound Libraries for GSK 690693

GSK 690693 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for GSK 690693

M. Wt	425.48
Formula	C₂₁H₂₇N₇O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	937174-76-0
PubChem ID	90488916
InChi Key	WONPMIMNXYCXKK-AWEZNQCLSA-N
Smiles	NC1=NON=C1C(N3CC)=NC2=C3C(CO[C@@H]4CNCCC4)=CN=C2C#CC(C)(C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for GSK 690693

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.27	50

Preparing Stock Solutions for GSK 690693

The following data is based on the product molecular weight 425.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.70 mL	23.50 mL	47.01 mL
2.5 mM	0.94 mL	4.70 mL	9.40 mL
5 mM	0.47 mL	2.35 mL	4.70 mL
25 mM	0.09 mL	0.47 mL	0.94 mL

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References for GSK 690693

References are publications that support the biological activity of the product.

Rhodes Characterization of an Akt inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res. 2008 PMID: 18381444
Heerding Identification of 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{(3S)-3-piperidinylmethoxyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J.Med.Chem. 2008 PMID: 18800763