Key Product Details
Description: | Potent and selective dual Akt1 and 2 inhibitor |
Alternative Names: | Akt Inhibitor VIII |
Chemical Name: | 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 551.64 |
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Citations for Akti-1/2 (3)
Citations are publications that use Bio-Techne products. Selected citations for Akti-1/2 include:
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Kodaka et al.
(2020)
Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells.
PLoS One.
15:e0231265
PMID: 32267872 -
Perkins et al.
(2018)
Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling.
Nat.Immunol..
19:1309
PMID: 30397349 -
Zhong et al.
(2018)
Tyro3 is a podocyte protective factor in glomerular disease.
JCI Insight.
3
PMID: 30429374
There are no citations that match your criteria.
Customer Reviews for Akti-1/2 (2)
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Species: HumanAssay Type: In VitroCell Line/Tissue: OsteosarcomaHuman osteosarcoma cells were incubated with 10 μM Akti-1/2 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. Akti-1/2 abolished LPA-induced COX-2 expression.
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Species: HumanAssay Type: In VitroCell Line/Tissue: MG-63 osteosarcoma cellsMG-63 cells were incubated with PD169316 (25 μM), LY294002 (10 μM) or Akt-1/2 (5 μM Akt-I) for 30 min prior to 15d-PGJ2 treatment (20 μM) for 1 h to follow pAkt expression using Western blot. Akt-1/2 completely blocked 15d-PGJ2-induced Akt phosphorylation in MG-63 cells.
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