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Akti-1/2

Tocris Bioscience a Bio-Techne Brand

Akti-1/2 | CAS No. 612847-09-3 | Potent and selective dual Akt1 and 2 inhibitor
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Introduction to Tocris

Key Product Details

Description: Potent and selective dual Akt1 and 2 inhibitor
Alternative Names: Akt Inhibitor VIII
Chemical Name: 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one
Purity: ≥98% (HPLC)
Molecular Weight: 551.64

Citations for Akti-1/2 (3)

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Customer Reviews for Akti-1/2 (2)

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  • Akti-1/2 blocks LPA-mediated COX-2 expression
    Name: Peter Cruz
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Human osteosarcoma cells were incubated with 10 μM Akti-1/2 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. Akti-1/2 abolished LPA-induced COX-2 expression.
    Akti-1/2 Serum 5773
  • Akt-1/2 blocks 15d-PGJ2-induced Akt phosphorylation
    Name: Christopher Trummer
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: MG-63 osteosarcoma cells
    MG-63 cells were incubated with PD169316 (25 μM), LY294002 (10 μM) or Akt-1/2 (5 μM Akt-I) for 30 min prior to 15d-PGJ2 treatment (20 μM) for 1 h to follow pAkt expression using Western blot. Akt-1/2 completely blocked 15d-PGJ2-induced Akt phosphorylation in MG-63 cells.
    Akti-1/2 Serum 5773

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Product Documents for Akti-1/2

Certificate of Analysis

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