AZD 5363

Name: AZD 5363
Brand: Tocris Bioscience
SKU: 6978

Tocris Bioscience a Bio-Techne Brand

Catalog # 6978

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Key Product Details

Description:	Potent pan-AKT inhibitor
Alternative Names:	Capivasertib
Chemical Name:	4-Amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	428.92

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Biological Activity for AZD 5363

AZD 5363 is a potent pan-AKT inhibitor (IC₅₀ values are 3, 7 and 7 nM for AKt 1, 2 and 3, respectively). Also inhibits P70S6K, PKA, ROCK2 and ROCK1 (IC₅₀ values are 6, 7, 60 and 470 nM, respectively). Inhibits growth of tumor cell lines in vitro, particularly breast, endometrial, gastric, hematologic and prostate cancers. Inhibits growth of human tumor xenografts in mice. Enhances in vivo antitumor effects of Docetaxel (Cat. No. 4056) and Lapatinib (Cat. No. 6811). Orally bioavailable.

Compound Libraries for AZD 5363

AZD 5363 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AZD 5363

M. Wt	428.92
Formula	C₂₁H₂₅ClN₆O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1143532-39-1
PubChem ID	25227436
InChi Key	JDUBGYFRJFOXQC-KRWDZBQOSA-N
Smiles	NC1(CCN(CC1)C1=C2C=CNC2=NC=N1)C(=O)N[C@@H](CCO)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 5363

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.89	100

Preparing Stock Solutions for AZD 5363

The following data is based on the product molecular weight 428.92.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.66 mL	23.31 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.17 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for AZD 5363

References are publications that support the biological activity of the product.

Davies Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol.Cancer Ther. 2012 PMID: 22294718

Citations for AZD 5363

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