Perifosine

Name: Perifosine
Brand: Tocris Bioscience
SKU: 6087

Tocris Bioscience, part of Bio-Techne | Catalog # 6087

Citations (7)

COA / SDS

PKB/Akt inhibitor; also modulates Kv2.1 current

Key Product Details

Description:	PKB/Akt inhibitor; also modulates K_v2.1 current
Alternative Names:	KRX-0401
Chemical Name:	Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate
Purity:	≥98% (HPLC)
Molecular Weight:	461.66

View Full Technical Details for Perifosine

Technical Data
Citations

Biological Activity for Perifosine

Perifosine is a PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases K_v2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.

Technical Data for Perifosine

M. Wt	461.66
Formula	C₂₅H₅₂NO₄P
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	157716-52-4
PubChem ID	148177
InChi Key	SZFPYBIJACMNJV-UHFFFAOYSA-N
Smiles	CCCCCCCCCCCCCCCCCCOP([O-])(OC1CC[N+](C)(CC1)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Perifosine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	46.17	100
	ethanol	46.17	100

Preparing Stock Solutions for Perifosine

The following data is based on the product molecular weight 461.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.83 mL	21.66 mL
5 mM	0.43 mL	2.17 mL	4.33 mL
10 mM	0.22 mL	1.08 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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References for Perifosine

References are publications that support the biological activity of the product.

Fu Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res. 2009 PMID: 19920197
Tazzari Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. Cancer Res. 2008 PMID: 19010914
Delgado-Ramírez Modulation of the voltage-gated potassium channel K_v2.1 by the anti-tumor alkylphospholipid perifosine. Pharmacol Rep. 2016 PMID: 26922553