Perifosine

Tocris Bioscience, part of Bio-Techne | Catalog # 6087

PKB/Akt inhibitor; also modulates Kv2.1 current
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Key Product Details

Description

PKB/Akt inhibitor; also modulates Kv2.1 current

Alternative Names

KRX-0401

View all Akt (Protein Kinase B) Inhibitors »

Product Description

Perifosine is a PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases Kv2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.

Product Specifications

Molecular Weight

461.66

Formula

C25H52NO4P

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

Octadecyl-(1,1-dimethyl-4-piperidylio) phosphate

CAS Number

157716-52-4

PubChem ID

148177

InChI Key

SZFPYBIJACMNJV-UHFFFAOYSA-N

SMILES

CCCCCCCCCCCCCCCCCCOP([O-])(OC1CC[N+](C)(CC1)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 46.17 100
Ethanol 46.17 100

Preparing Stock Solutions for Perifosine

The following data is based on the product molecular weight 461.66

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.83 mL 21.66 mL
5 mM 0.43 mL 2.17 mL 4.33 mL
10 mM 0.22 mL 1.08 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Documents for Perifosine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Perifosine

For research use only

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