10 results for "TRPA1 Small Molecules and Peptides" in Products
TRPA1: Small Molecules and Peptides
Transient receptor potential ion channels (TRPCs) are a superfamily of six transmembrane segment-spanning, gated cation channels. TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds and plays a role in both nociceptor and hair cell transduction. It is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. Blocking TRPA1 may be a therapeutic target for treating cold hyperalgesia caused by inflammation and nerve damage. It is now known that TRPA1 protein is also widely expressed outside of the CNS and is dys-regulated during oncogenic transformation.
Potent and selective TRPA1 channel activator
| Chemical Name: | 2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide |
| Purity: | ≥98% (HPLC) |
Reversible TRPA1 channel blocker
| Chemical Name: | 4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime |
| Purity: | ≥98% (HPLC) |
Selective TRPA1 channel blocker
| Alternate Names: | A-079 |
| Chemical Name: | (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime |
| Purity: | ≥98% (HPLC) |
Selective TRPA1 blocker
| Chemical Name: | 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide |
| Purity: | ≥98% (HPLC) |
Potent and selective TRPA1 antagonist
| Chemical Name: | 1-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one |
| Purity: | ≥98% (HPLC) |
Selective TRPA1 activator
| Chemical Name: | (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid |
| Purity: | ≥98% (HPLC) |
Potent and selective TRPA1 antagonist. Brain penetrant and orally bioavailable
| Chemical Name: | (1R,2R)-2-[(4-Fluorophenyl)amino]-1-(trifluoromethyl)cyclohexanol |
| Purity: | ≥98% (HPLC) |
Activates cold receptors. Cooling agent
| Alternate Names: | AG 3-5 |
| Chemical Name: | 3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one |
| Purity: | ≥98% (HPLC) |
Cyclooxygenase inhibitor
| Chemical Name: | 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol |
| Purity: | ≥98% (HPLC) |
Potent and selective FAAH inhibitor
| Chemical Name: | Cyclohexylcarbamic acid 3'-(Aminocarbonyl)-[1,1'-biphenyl]-3-yl ester |
| Purity: | ≥98% (HPLC) |
