A 967079 (also known as A-079) is a selective TRPA1 channel blocker (IC₅₀ values are 67 and 289 nM at human and rat TRPA1 receptors respectively) that displays 1000-fold selectivity for TRPA1 over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. A 967079 exhibits analgesic effects in a rat osteoarthritic pain model.

External Portal Information

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of A 967079 (A-079) is reviewed.

Product Specifications

Molecular Weight

207.24

Formula

C₁₂H₁₄FNO

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime

CAS Number

1170613-55-4

PubChem ID

42641861

InChI Key

HKROEBDHHKMNBZ-CHBKHGQFSA-N

SMILES

FC1=CC=C(/C=C(C)/C(CC)=N/O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.72	100
	Ethanol	20.72	100

Preparing Stock Solutions for A 967079

The following data is based on the product molecular weight 207.24

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.83 mL	24.13 mL	48.25 mL
5 mM	0.97 mL	4.83 mL	9.65 mL
10 mM	0.48 mL	2.41 mL	4.83 mL
50 mM	0.10 mL	0.48 mL	0.97 mL

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Background References

References are publications that support the biological activity of the product.

Chen Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain 2011 PMID: 21402443
McGaraughty TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol.Pain 2010 PMID: 20205719

A 967079

Tocris Bioscience, part of Bio-Techne | Catalog # 4716

Key Product Details

Description

Alternative Names

View all TRPA1 Blockers »

Product Description