A 967079

Name: A 967079
Brand: Tocris Bioscience
SKU: 4716
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4716

(1)

Citations (53)

COA / SDS

Selective TRPA1 channel blocker

Key Product Details

Description:	Selective TRPA1 channel blocker
Alternative Names:	A-079
Chemical Name:	(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime
Purity:	≥98% (HPLC)
Molecular Weight:	207.24

View Full Technical Details for A 967079

Technical Data
Citations / Reviews (1)

Biological Activity for A 967079

A 967079 (also known as A-079) is a selective TRPA1 channel blocker (IC₅₀ values are 67 and 289 nM at human and rat TRPA1 receptors respectively) that displays 1000-fold selectivity for TRPA1 over other TRP channels, and is >150-fold selective over 75 other ion channels, enzymes and G-protein-coupled receptors. A 967079 exhibits analgesic effects in a rat osteoarthritic pain model.

Compound Libraries for A 967079

A 967079 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

External Portal Information

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of A 967079 (A-079) is reviewed.

Technical Data for A 967079

M. Wt	207.24
Formula	C₁₂H₁₄FNO
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1170613-55-4
PubChem ID	42641861
InChi Key	HKROEBDHHKMNBZ-CHBKHGQFSA-N
Smiles	FC1=CC=C(/C=C(C)/C(CC)=N/O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 967079

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.72	100
	ethanol	20.72	100

Preparing Stock Solutions for A 967079

The following data is based on the product molecular weight 207.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.83 mL	24.13 mL	48.25 mL
5 mM	0.97 mL	4.83 mL	9.65 mL
10 mM	0.48 mL	2.41 mL	4.83 mL
50 mM	0.10 mL	0.48 mL	0.97 mL

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References for A 967079

References are publications that support the biological activity of the product.

Chen Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation. Pain 2011 PMID: 21402443
McGaraughty TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Mol.Pain 2010 PMID: 20205719