AM 0902
Tocris Bioscience, part of Bio-Techne | Catalog # 5914
Potent and selective TRPA1 antagonist
Product Description
AM 0902 is a potent and selective TRPA1 antagonist (IC50 = 0.02 μM for human TRPA1). Exhibits no siginificant activity against human TRPV1 or TRPV4, and rat TRPV1, TRPV3 or TRPM8. Exhibits efficacy in a rat pain model. Orally bioavailable.Product Specifications
Molecular Weight
370.79
Formula
C17H15ClN6O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-[[3-[2-(4-Chlorophenyl)ethyl]-1,2,4-oxadiazol-5-yl]methyl]-1,7-dihydro-7-methyl-6H-purin-6-one
CAS Number
1883711-97-4
PubChem ID
73297271
InChI Key
AWJBWNUUODWOKQ-UHFFFAOYSA-N
SMILES
CN1C=NC2=C1C(N(C=N2)CC3=NC(CCC4=CC=C(C=C4)Cl)=NO3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.08 | 100 |
Preparing Stock Solutions
for AM 0902
The following data is based on the product molecular weight 370.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.70 mL | 13.48 mL | 26.97 mL |
| 5 mM | 0.54 mL | 2.70 mL | 5.39 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.70 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schenkel Optimization of a novel quinazolinone-based series of transient receptor potential A1 (TRPA1) antagonists demonstrating potent in vivo activity. J.Med.Chem. 2016 PMID: 26942860
Product Specific Notices for AM 0902
For research use only
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